We developed, synthesized, and tested a multifunctional nanostructured lipid nanocarrier- based system (NLCS) for efficient delivery of an anticancer drug and siRNA directly into the lungs by inhalation. The system contains: (1) nanostructured lipid carriers (NLC); (2) anticancer drug (doxorubicin or paclitaxel); (3) siRNA targeted to MRP1 mRNA as a...
Semidwarfism has been used extensively in row crops and horticulture to promote yield, reduce lodging, and improve harvest index, and it might have similar benefits for trees for short-rotation forestry or energy plantations, reclamation, phytoremediation, or other applications. We studied the effects of the dominant semidwarfism transgenes GA Insensitive (GAI)...
Information on land cover at global and continental scales is critical for addressing a range of ecological, socioeconomic and policy questions. Global land cover maps have evolved rapidly in the last decade, but efforts to evaluate map uncertainties have been limited, especially in remote areas like Northern Eurasia. Northern Eurasia...
Transgenic down-regulation of the Pt4CL1 gene family encoding 4-coumarate:coenzyme A ligase (4CL) has been reported as a
means for reducing lignin content in cell walls and increasing overall growth rates, thereby improving feedstock quality for
paper and bioethanol production. Using hybrid poplar (Populus tremula 3 Populus alba), we applied this...