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Does Aqueous Fullerene Inhibit the Growth of Saccharomyces cerevisiae or Escherichia coli?

Creator:

Hadduck, Alex N., Hindagolla, Vihangi, Contreras, Alison E., Li, Qilin, and Bakalinsky, Alan T.

Abstract:

Studies reporting on potentially toxic interactions between aqueous fullerene nanoparticles (nC₆₀) and microorganisms have been contradictory. When known confounding factors were avoided, growth yields of Saccharomyces cerevisiae and Escherichia coli cultured in the presence and absence of independently prepared lots of underivatized nC₆₀ were found not to be significantly different.

Resource Type:

Article

Full Text:

Vihangi Hindagolla,1 Alison E. Contreras,2 Qilin Li,2 and Alan T. Bakalinsky1* Department of Food Science
Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity

Creator:

Smith, Mark R., Boenzli, Matthew G., Hindagolla, Vihangi, Ding, Jun, Miller, John M., Hutchison, James E., Greenwood, Jeffrey A., Abeliovich, Hagai, and Bakalinsky, Alan T.

Abstract:

Positively-charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.

Resource Type:

Article