Just as scientific knowledge is constructed using distinct modes of inquiry (e.g., experimental or historical), arguments constructed during science instruction may vary depending on the mode of inquiry underlying the topic. The purpose of this study was to examine whether and how secondary science teachers construct scientific arguments during instruction...
The effect of process variations under supercritical conditions on cyproconazole retention and distribution in ponderosa pine sapwood boards was assessed. While pressure and temperature appeared to affect biocide solubility to some extent, the overall results suggested that biocide movement into wood was influenced more by diffusion than bulk flow. Biocide...
Purpose of the Study: We tested a life-span model of combat exposure on posttraumatic stress disorder (PTSD) symptoms in later life, examining the direct and indirect effects of prewar, warzone, and postwar factors.
Design and Methods: The sample included 947 male World War II and Korean War veterans from the...
This paper presents a new mechanical design of an anthropomorphic robot hand. The hand is designed such that it is adaptive, backdrivable, modularized to provide both dexterity and robustness. The hand has 18 joints, 14 degrees of freedom, and a new joint mechanism called an active DIP-PIP joint for the...
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Background:
The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies.
Results:
Wild type...
We investigated 32 net primary productivity (NPP) models by assessing skills to reproduce integrated NPP in the Arctic Ocean. The models were provided with two sources each of surface chlorophyll-a concentration (chlorophyll), photosynthetically available radiation (PAR), sea surface temperature (SST), and mixed-layer depth (MLD). The models were most sensitive to...
We demonstrate remarkably strong nonlinear terahertz (THz) effects in an intrinsic GaAs wafer patterned with a nanometer-width slot antenna array. The antenna near-field reaches 20 MV/cm due to the huge field enhancement in the plasmonic nano-structure (field enhancement factor, α ≅ 50). The THz fields are strong enough to generate high density...
Microglia and reactive astrocytes accumulate in the spinal cord of rats expressing the Amyotrophic lateral sclerosis (ALS)-linked SOD1ᴳ⁹³ᴬ mutation. We previously reported that the rapid progression of paralysis in ALS rats is associated with the appearance of prolifer- ative astrocyte-like cells that surround motor neurons. These cells, designated as Aberrant...
Common methods for assessment of surface checking in decorative plywood panels rely on manual handling and visual inspection of specimens, a laborious procedure practically limiting the number of materials and variables that may be considered within one project. In this study, a new automated optical method for detection and measurement...