Index Catalog // ScholarsArchive@OSU

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., Gafken, Philip R., Soge, Olusegun O., Holmes, King K., Jerse, Ann E., Unemo, Magnus, and Sikora, Aleksandra E.
Abstract:: Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...
Resource Type:: Article
Full Text:: polymorphisms at the nucleotide and amino acid levels showed that these vaccine candidates are highly conserved

Ribonucleotide Reductase Association with Mammalian Liver Mitochondria

Creator:: Chimploy, Korakod, Song, Shiwei, Wheeler, Linda J., and Mathews, Christopher K.
Abstract:: Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly asymmetric, and this asymmetry probably contributes toward the elevated mutation rate for the mitochondrial genome as compared with the nuclear genome. To understand this asymmetry, we must identify pathways for synthesis and accumulation of dNTPs within mitochondria. We have identified ribonucleotide reductase...
Resource Type:: Article
Full Text:: . Nucleic Acids Res. 39 , 1360–1371 3. Mathews, C. K., and Ji, J. (1992) DNA precursor asymmetries

Yeast POS5 NADH Kinase: Effects of a Mitochondrial Mutator Mutation on Mitochondrial Nucleotides

Creator:: Wheeler, Linda J. and Mathews, Christopher K.
Abstract:: Saccharomyces cerevisiae contains three NAD⁺/NADH kinases, one of which is localized in mitochondria and phosphorylates NADH in preference to NAD⁺. Strand et al (Euk. Cell 2:809 (2003)) reported that a yeast mutation in POS5, which encodes the mitochondrial NADH kinase, is a mutator, specific for mitochondrial genes. Because of the...
Resource Type:: Article
Full Text:: . Nucleic Acids Res. 38, e85. 17. Wheeler, L. J., Rajagopal, I., and Mathews, C. K. (2005) Stimulation of

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Creator:: Jie, Jing, Löhr, Frank, and Barbar, Elisar
Abstract:: Intrinsically disordered protein (IDP) duplexes composed of two IDP chains cross-linked by bivalent partner proteins form scaffolds for assembly of multiprotein complexes. The N-terminal domain of dynein intermediate chain (N-IC) is one such IDP that forms a bivalent scaffold with multiple dynein light chains including LC8, a hub protein that...
Resource Type:: Article
Full Text:: Workbench. Nucleic Acids Res. 41, W349–357 29. Peckham, M., and Knight, P. J. (2009) When a predicted

Development and performance evaluation of calf diarrhea pathogen nucleic acid purification and detection workflow

Creator:: Schroeder, Megan E., Bounpheng, Mangkey A., Rodgers, Sandy, Baker, Rocky J., Black, Wendy, Naikare, Hemant, Velayudhan, Binu, Sneed, Loyd, Szonyi, Barbara, and Clavijo, Alfonso
Abstract:: Calf diarrhea (scours) is a primary cause of illness and death in young calves. Significant economic losses associated with this disease include morbidity, mortality, and direct cost of treatment. Multiple pathogens are responsible for infectious diarrhea, including, but not limited to, Bovine coronavirus (BCV), bovine Rotavirus A (BRV), and Cryptosporidium...
Resource Type:: Article
Full Text:: nucleic acid detection workflow From the Texas Veterinary Medical Diagnostic Laboratory, College Station

Drug Repurposing in Chemical Genomics: Can We Learn from the Past to Improve the Future?

Creator:: Bisson, William H.
Abstract:: More needs to be done by the private sector to optimize the drug discovery and development pipeline. In addition, significant efforts should also be focused on the understanding of mechanism of diseases, on the characterization of unexplored biochemical pathways and on the validation of new protein targets. Chemical genomics, which...
Resource Type:: Article
Full Text:: -conquer docking approach. Nucleic Acids Res., 2012, 40, 393-399. [41]. Available from: http://www.nccr

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Creator:: Shorey, Lyndsey E., Hagman, Amanda M., Williams, David E., Ho, Emily, Dashwood, Roderick H., and Benninghoff, Abby D.
Abstract:: Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Resource Type:: Article
Full Text:: Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America, 2

SNP-Based Differentiation of Phytophthora infestans Clonal Lineages Using Locked Nucleic Acid Probes and High-Resolution Melt Analysis

Creator:: Hansen, Zachariah R., Knaus, Brian J., Tabima, Javier F., Press, Caroline M., Judelson, Howard S., Grünwald, Niklaus J., and Smart, Christine D.
Abstract:: Phytophthora infestans, the cause of the devastating late blight disease of potato and tomato, exhibits a clonal reproductive lifestyle in North America. Phenotypes such as fungicide sensitivity and host preference are conserved among individuals within clonal lineages, while substantial phenotypic differences can exist between lineages. Whole P. infestans genomes were...
Resource Type:: Article
Full Text:: Phytophthora infestans Clonal Lineages Using Locked Nucleic Acid Probes and High-Resolution Melt Analysis

Activity and phylogenetic diversity of bacterial cells with high and low nucleic acid content and electron transport system activity in an upwelling ecosystem

Creator:: Longnecker, K., Sherr, Barry F., and Sherr, Evelyn
Abstract:: We evaluated whether bacteria with higher cell-specific nucleic acid content (HNA) or an active electron transport system, i.e., positive for reduction of 5-cyano-2,3-ditolyl tetrazolium chloride (CTC), were responsible for the bulk of bacterioplankton metabolic activity. We also examined whether the phylogenetic diversity of HNA and CTC-positive cells differed from the...
Resource Type:: Article
Full Text:: Cells with High and Low Nucleic Acid Content and Electron Transport System Activity in an Upwelling

ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format

Creator:: Thomas, Dennis G., Gaheen, Sharon, Harper, Stacey L., Fritts, Martin, Klaessig, Fred, Hahn-Dantona, Elizabeth, Paik, David, Pan, Sue, Stafford, Grace A., Freund, Elaine T., Klemm, Juli D., and Baker, Nathan A.
Abstract:: Background and motivation: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and...
Resource Type:: Article
Full Text:: their molecular structure, biochemical role, and function [28]. The types of information needed to

ScholarsArchive@OSU

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Ribonucleotide Reductase Association with Mammalian Liver Mitochondria

Yeast POS5 NADH Kinase: Effects of a Mitochondrial Mutator Mutation on Mitochondrial Nucleotides

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Development and performance evaluation of calf diarrhea pathogen nucleic acid purification and detection workflow

Drug Repurposing in Chemical Genomics: Can We Learn from the Past to Improve the Future?

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

SNP-Based Differentiation of Phytophthora infestans Clonal Lineages Using Locked Nucleic Acid Probes and High-Resolution Melt Analysis

Activity and phylogenetic diversity of bacterial cells with high and low nucleic acid content and electron transport system activity in an upwelling ecosystem

ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format

Limit your search

Academic Affiliation

Conference Name

Conference Section/Track

Creator

Contributor

Date

Decade

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search