Dietary restriction (DR) is the gold standard intervention used to delay aging, and much recent research has focused on
the identification of possible DR mimetics. Energy sensing pathways, including insulin/IGF1 signaling, sirtuins, and
mammalian Target of Rapamycin (mTOR), have been proposed as pathways involved in the antiaging actions of DR,...
Because rapamycin, an inhibitor of the nutrient sensor mammalian target of rapamycin, and dietary restriction both increase life span of mice, it has been hypothesized that they act through similar mechanisms. To test this hypothesis, we compared various biological parameters in dietary restriction mice (40% food restriction) and mice fed...
Parasites and pathogens influence the size and stability of wildlife populations, yet many population models ignore
the population-level effects of pathogens. Standard survival analysis methods (e.g., accelerated failure time models)
are used to assess how survival rates are influenced by disease. However, they assume that each individual is equally
susceptible...
To test the utility of otolith chemical composition as a tool for determining the natal stream of origin for salmon, we examined water chemistry and otoliths of juvenile and adult Chum Salmon Oncorhynchus keta and Coho Salmon O. kisutch from three watersheds (five rivers) in the Norton Sound region of...
The myxozoan parasite Ceratomyxa shasta is a significant pathogen of juvenile salmonids in the Pacific Northwest of North America and is limiting recovery of Chinook (Oncorhynchus tshawytscha) and coho (O. kisutch) salmon populations in the Klamath River. We conducted a 5-year monitoring program that comprised concurrent sentinel fish exposures and...
Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longevity effect,...
Saltwater-adapted juvenile chinook salmon Oncorhynchus tshawytscha exposed to aromatic and chlorinated compounds, representative of contaminants found in urban estuaries in Puget Sound, have a higher susceptibility to vibriosis than do fish exposed only to the solvent vehicle. Susceptibility to vibriosis was assessed by examining the percent cumulative mortality of the...
Juvenile salmonids display highly variable spatial and temporal patterns of early dispersal that are influenced by density-dependent and density-independent factors.
Although juvenile coho salmon (Oncorhynchus kisutch) movement patterns in streams and their relationship with body mass and growth have been examined in previous studies, most observations were limited to one...
Better fisheries management is often given as one justification for research on improving forecasts of fish survival. However, the value gained from expected improvements in forecast skill in terms of achieving management goals is rarely quantified as part of research objectives. Using Monte Carlo simulations of population dynamics, we assessed...
A critical seasonal event for anadromous Chinook salmon (Oncorhynchus tshawytscha) is the time at which adults migrate from the ocean to breed in freshwater. We investigated whether allelic variation at the circadian rhythm genes, OtsClock1a and OtsClock1b, underlies genetic control of migration timing among 42 populations in North America. We...