Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to pathogenesis has yet to be determined and may reveal efficacious targets for potential treatment. In this study, we show that the interleukin (IL)-10 signaling pathway modulates Ebola pathogenesis. IL-10 [superscript -...
BACKGROUND: Increasing emphasis in performance-based payment, public reporting, and quality improvement
(QI) has led to widespread interest in measuring and improving the quality of care. By 2014, hospice programs
will be required to report quality data to the federal government or incur financial penalties. With this increased
interest in quality...
Significance: Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens. Recent Advances: Plasmodial and...
In 2012, heads of local law enforcement agencies in Benton County, Oregon, contacted researchers at Oregon State University to discuss a problem: a sharp rise in the amount of contact between police and suspects displaying symptoms of mental illness. This initial contact led to an ongoing collaborative examination of the...
Traumatic brain injury (TBI) is a significant public health issue due to the incidence,
complexity, and cost associated with treatment. The purpose of this study was to
determine physical activity (PA) knowledge, attitudes, intentions, and barriers
among individuals with a TBI undergoing outpatient rehabilitation. Seventeen
participants completed a series of...
The sensitivity of the tropics to climate change, particularly the amplitude of glacial‐to‐interglacial changes in sea surface temperature (SST), is one of the great controversies in paleoclimatology. Here we reassess faunal estimates of ice age SSTs, focusing on the problem of no‐analog planktonic foraminiferal assemblages in the equatorial oceans that...
We examine the utility of the uranium (U) content of planktonic foraminifera tests as an indicator of past changes in seawater U content. The U/Ca ratio in foraminifera from Atlantic and Caribbean cores in constant in the Holocene and decreases by ~25% during the last glacial period. Magnesium/calcium (Mg/Ca) ratios...
The feeding habits of pelagic, juvenile rockfishes (Sebastes spp.) collected off Oregon in 2002, and Oregon and Washington in 2006, were examined using stomach content and stable isotope analyses. Sampling occurred along a series of transects across the shelf between Crescent City, California (Lat. 41°54.0′), and Newport, Oregon (Lat. 44°39.0′),...
We examine the 0–100 Ma paleoceanographic record retained in pelagic clay from the South Pacific Gyre (SPG) by analyzing 47 major, trace, and rare earth elements in bulk sediment in 206 samples from seven sites drilled during Integrated Ocean Drilling Program Expedition 329. We use multivariate statistical analyses (Q-mode factor analysis...
Dating pelagic clay can be a challenge due to its slow sedimentation rate, post-depositional alteration, and lack of biogenic deposition. Co-based dating techniques have the potential to create age models in pelagic clay under the assumption that the flux of non-detrital Co to the seafloor is spatially and temporally constant,...