Ocular infection by HSV-1 strain McKrae is neurovirulent in both mice and rabbits and causes fatal encephalitis in approximately 50% of animals. In addition, it spontaneously reactivates with high frequency relative to other HSV-1 strains in rabbits. We sequenced the McKrae strain genome and compared its coding protein sequences with...
The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic
prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well
tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be...
Variation in fluvial suspended sediment–discharge behavior is generally thought to be the product of changes in processes governing the delivery of sediment and water to the channel. The objective of this study was to infer sediment supply dynamics from the response of suspended sediment behavior to antecedent hydrologic factors. The...
Radiation damage caused by fission fragments to metal surfaces is an important research topic. Thin titanium foils were irradiated with a continuous wave beam of 132 MeV ¹³²Xe+²⁹ at the current intensity of 2 pnA. Pre- and post-irradiated surface topologies were investigated using atomic force microscopy and the observed defects...
The copepod Tigriopus californicus shows extensive population divergence and is becoming a model for understanding allopatric differentiation and the early stages of speciation. Here, we report a high-quality reference genome for one population (similar to 190 megabases across 12 scaffolds, and similar to 15,500 protein-coding genes). Comparison with other arthropods...
This study is an investigation into the roles of wildfire and changing agricultural practices in controlling the inter-decadal scale trends of suspended sediment production from semi-arid mountainous rivers. In the test case, a decreasing trend in suspended sediment concentrations was found in the lower Salinas River, California between 1967 and...
What is the nature of evolutionary divergence of the jaw skeleton within the genus Oncorhynchus? How can two associated bones evolve new shapes and still maintain functional integration? Here, we introduce and test a ‘concordance’ hypothesis, in which an extraordinary matching of the evolutionary shape changes of the dentary and...
In order to better understand the relationships among current Nostocales cyanobacterial blooms, eight genomes were sequenced from cultured isolates or from environmental metagenomes of recent planktonic Nostocales blooms. Phylogenomic analysis of publicly available sequences placed the new genomes among a group of 15 genomes from four continents in a distinct...
The fission Time Projection Chamber (fissionTPC) is a compact (15 cm diameter) two-chamber
MICROMEGAS TPC designed to make precision cross-section measurements of neutron-induced fission.
The actinide targets are placed on the central cathode and irradiated with a neutron beam that passes
axially through the TPC inducing fission in the target....
The Surface Ocean CO2 Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO2 (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3...