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Filtering by: Creator Beaudry, M-C. Resource Type Dissertation Subject Alkaloids -- Synthesis

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Creator:

Vellucci, Jessica K.

Abstract:

Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...

Resource Type:

Dissertation

Full Text:

: ______________________________________________________ Christopher M. Beaudry Aminal radical intermediates were generated by the method of
Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:

Veerasamy, Nagarathanam

Abstract:

The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...

Resource Type:

Dissertation

Full Text:

.) THF, 60 °C; 3 M HCl in MeOH 98% N H Cl NaBH4, MeOH 99% N H (-)-Cermizine C (1.9) 1.1.1 1.1.3