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Filtering by: Creator Carter, Myrtle Miller Resource Type Dissertation Subject Antibiotics -- Synthesis

Biosynthesis and modification of the antibiotic enduracidin

Creator:

Goebel, Neal C.

Abstract:

The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...

Resource Type:

Dissertation
Biosynthetic engineering of new pactamycins

Creator:

Lu, Wanli

Abstract:

Among the myriad of naturally occurring bioactive compounds are the aminocyclopentitol-containing natural products that represent a family of sugar-derived microbial secondary metabolites, such as the antibiotics pactamycin, allosamidin, and trehazolin. Pactamycin, a structurally unique aminocyclitol antibiotic isolated from Streptomyces pactum, consists of a 5-membered ring aminocyclitol (cyclopentitol) unit, two aromatic...

Resource Type:

Dissertation

Full Text:

than P site as proposed previously (Carter et al., 2000). The two aromatic rings stay in the
Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly

Creator:

Guo, Jincan

Resource Type:

Dissertation
Advanced studies of blasticidin S biosynthesis

Creator:

Zhang, Qibo

Resource Type:

Dissertation