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Filtering by: Creator Gut, Larry J. Remove constraint Creator: Gut, Larry J. Resource Type Dissertation Remove constraint Resource Type: Dissertation Subject Antineoplastic agents Remove constraint Subject: Antineoplastic agents

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Disposition of C H N O S in rats and three antiulcer agents in llamas

Creator:

Limsakun, Tharin

Resource Type:

Dissertation

Full Text:

advisor, Dr. J. Mark Christensen, and Dr. J. W. Ayres for their assistance, patience, encouragement, and
Chlorophyllin anticarcinogenesis in the rainbow trout model

Creator:

Breinholt, Vibeke

Resource Type:

Dissertation

Full Text:

complex formation between CHL and AFB, in the gut and concomitantly Redacted for Privacy reduced
A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:

Myzak, Melinda C.

Abstract:

Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...

Resource Type:

Dissertation
Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:

Nian, Hui

Abstract:

Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...

Resource Type:

Dissertation
Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:

Larsen, Christine A.

Abstract:

Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...

Resource Type:

Dissertation
Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

Creator:

Hoyt, Dale G.

Abstract:

Previous investigation showed that 20 mg/kg BCNU caused inhibition of sulfobromophthalein (BSP) excretion and inhibited bile salt independent bile flow (BSIF) in rats by 48 h after treatment (Hoyt, 1984). The present investigation demonstrated that BCNU inhibited the canalicular step in the excretion of BSP. This was indicated by the...

Resource Type:

Dissertation

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Academic Affiliation

College of Pharmacy2
Biochemistry and Biophysics1

Advisor

Dashwood, Roderick H.2
Bailey, George S.1
Christensen, John Mark1
Dashwood, Rod1
Ho, Emily1
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Commencement Year

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Current results range from 1986 to 2010

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Committee Member

Ho, Emily2
Williams, David2
Buermeyer, Andrew1
Chang, Chih-Hung (Alex)1
Cope, Rhian1
more Committee Members »

Creator

Breinholt, Vibeke1
Hoyt, Dale G.1
Larsen, Christine A.1
Limsakun, Tharin1
Myzak, Melinda C.1
more Creators »

Date

Date range begin – Date range end

Current results range from 1985 to 2010

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Decade

2010-20192
2000-20091
1990-19992
1980-19891

Degree Field

Molecular and Cellular Biology2
Pharmacy2
Biochemistry and Biophysics1
Toxicology1

Degree Level

Doctoral6

Degree Name

Doctor of Philosophy (Ph.D.)6

Language

English [eng]6

License

All rights reserved2

Non-Academic Affiliation

Oregon State University. Graduate School6

Peer Reviewed

No6

Resource Type

Dissertation[remove]6

Rights Statement

Copyright Not Evaluated3
In Copyright3

Subject

Antineoplastic agents[remove]6
Histone deacetylase -- Inhibitors2
Antiulcer drugs1
Cancer -- Chemoprevention1
Chlorophyllin1
more Subjects »

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