Index Catalog // ScholarsArchive@OSU

Understanding chlamydial biology through genome sequencing and comparative genomics

Creator:: Jeffrey, Brendan
Abstract:: The human pathogen Chlamydia trachomatis displays different phenotypes between serovars both in vivo and in vitro. The study of chlamydial biology has been hampered by the lack of a tractable genetic system. Here, chlamydial isolates with known phenotypes as well as strains generated though recombination were fully sequenced to address...
Resource Type:: Dissertation
Full Text:: genomes and performed the genomic analyses. Brendan M. Jeffrey, Robert J. Suchland, and Daniel D

Recombination, resistance, and drug discovery in Chlamydia

Creator:: Sandoz, Kelsi
Abstract:: The intracellular life cycle of Chlamydia has been difficult to study due to the inability to genetically manipulate the bacteria. As a result, indirect methods have been employed to study the pathogen and the aspects that contribute to its unique intracellular life cycle. A wide variety of laboratory adapted strains,...
Resource Type:: Dissertation
Full Text:: Daniel D. Rockey wrote the manuscript, with Kelsi M. Sandoz and Robert J. Suchland contributing equally

An investigation of carbon and nitrogen metabolism through a genomic analysis of the genus Nitrobacter

Creator:: Starkenburg, Shawn R.
Abstract:: The chemolithoautotrophic nitrite oxidizing bacteria (NOB) participate in the biogeochemical cycling of nitrogen by catalyzing and conserving energy from the oxidation of nitrite (NO₂-) to nitrate (NO₃-) via a nitrite oxidoreductase (NXR). The main objective of this work was to comparatively annotate and analyze the genome sequences of Nitrobacter winogradskyi...
Resource Type:: Dissertation
Full Text:: Metabolism’ and manuscript preparation in Chapter 3. Daniel J. Arp contributed to manuscript preparation of

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Creator:: Early, Julie V.
Abstract:: Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
Resource Type:: Dissertation
Full Text:: immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium

Prokaryotes associated with marine crust

Creator:: Mason, Olivia Underwood
Abstract:: Oceanic crust covers nearly 70% of the Earth's surface, of which, the upper, sediment layer is estimated to harbor substantial microbial biomass. Marine crust; however, extends several kilometers beyond this surficial layer, and includes the basalt and gabbro layers. In particular, the basalt layer has high permeabilities which allows for...
Resource Type:: Dissertation
Full Text:: also like to thank my committee members, Drs. Michael S. Rappé, Ricardo M. Letelier, Mario E. Magana

Mechanisms for the interaction of environmental mycobacteria with host cells

Creator:: Harriff, Melanie J.
Abstract:: Environmental mycobacteria are important opportunistic pathogens for many hosts, including humans, cattle, and fish. Two well-studied species are Mycobacterium avium subsp. avium, a significant cause of disseminated bacterial disease in patients with AIDS, and Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in cattle. Many other species that are...
Resource Type:: Dissertation
Full Text:: . Johnson, J. Bartell, R. Davis, M. Walsh & M. Levi. 2001. Granulomatous skin lesions in moray eels

Genomic-assisted determination of the natural nutrient requirements of the cosmopolitan marine bacterium 'Candidatus Pelagibacter ubique'

Creator:: Tripp, H. James
Abstract:: To identify factors limiting 'Candidatus Pelagibacter ubique' maximum cell density and growth rate in pure culture on seawater, the genome sequence of 'Cand. P. ubique' was analyzed, culturing experiments with organic and inorganic nutrient additions were made, and radiotracer uptake experiments were performed. The genome was sequenced, custom data mining...
Resource Type:: Dissertation
Full Text:: cell yield increased an order of magnitude. But, increasing DMSP additions from 50 nM to 10 μM did

Physiological, proteomic, and whole-genome transcriptional responses of Nitrosomonas europaea to heavy metals (Zn²⁺,Cd²⁺, Cu²⁺, and Hg²⁺) and cyanide : identification of heavy metals and cyanide stress response genes

Creator:: Park, Sunhwa
Abstract:: Nitrosomonas europaea (ATCC19718) participates in the biological removal of nitrogen from wastewater by oxidizing ammonia to nitrite, the first step in nitrification. This bacterium is sensitive to heavy metals (Zn²⁺, Cd²⁺, Cu²⁺, and Hg²⁺) and cyanide, compounds commonly encountered in wastewater treatment plants. Therefore, we characterized physiological and transcriptional responses...
Resource Type:: Dissertation
Full Text:: - induced genes. N. europaea exposed to 3.4 M ZnCl2 showed about 61% inhibition in nitrification within

Molecular basis for Clostridium perfringens spore resistance to heat and other environmental stress factors

Creator:: Raju, Deepa
Abstract:: Clostridium perfringens type A isolates producing enterotoxin (CPE) are an important cause of both food poisoning (FP) and non food borne gastrointestinal diseases (NFBGID) in both humans and animals. C. perfringens type A food poisoning is caused by isolates carrying the CPE encoding gene (cpe) on the chromosome while the...
Resource Type:: Dissertation
Full Text:: , Daniel Paredes-Sabja, Nahid Mahfuz, Mike Waters, Ben Harrison and all the other members of the Sarker

Characterization of the genomic islands from tetracycline-resistant Chlamydia suis

Creator:: Dugan, Jae
Abstract:: Tetracycline (Tet)-resistant strains of Chlamydia suis were isolated from swine farms in the Midwest. The isolation of the resistant strains was significant because Tet is an antibiotic used to treat infections by veterinarians and doctors. One of the tetracycline (Tet)-resistant strains, R19, was able to survive in Tet up to...
Resource Type:: Dissertation
Full Text:: Tetracycline-resistant Chlamydia suis. Abstract approved: Daniel D. Rockey

ScholarsArchive@OSU

Understanding chlamydial biology through genome sequencing and comparative genomics

Recombination, resistance, and drug discovery in Chlamydia

An investigation of carbon and nitrogen metabolism through a genomic analysis of the genus Nitrobacter

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Prokaryotes associated with marine crust

Mechanisms for the interaction of environmental mycobacteria with host cells

Genomic-assisted determination of the natural nutrient requirements of the cosmopolitan marine bacterium 'Candidatus Pelagibacter ubique'

Physiological, proteomic, and whole-genome transcriptional responses of Nitrosomonas europaea to heavy metals (Zn²⁺,Cd²⁺, Cu²⁺, and Hg²⁺) and cyanide : identification of heavy metals and cyanide stress response genes

Molecular basis for Clostridium perfringens spore resistance to heat and other environmental stress factors

Characterization of the genomic islands from tetracycline-resistant Chlamydia suis

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search