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Filtering by: Creator Bartholomew, Jerri Lee Resource Type Dissertation Subject Cancer -- Immunological aspects

Modulation of chemically-induced hepatocarcinogenesis by indole-3-carbinol : mechanisms and species comparison

Creator:

Oganesian, Aram

Abstract:

There is plenty of evidence from epidemiology studies supporting a link between certain components in the human diet and cancer incidence. It is estimated that 3-4 million annual cases of cancer could be prevented worldwide just by changing dietary habits. In parts of the world where vegetables and fruits constitute...

Resource Type:

Dissertation

Full Text:

(1991). 15. A.T. Fong, J.D. Hendricks, R.H. Dashwood, S. Van Winkle, B.C. Lee, and G.S. Bailey
Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Creator:

Tilton, Susan C.

Abstract:

Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...

Resource Type:

Dissertation

Full Text:

, a semi-purified casein-based diet (Lee et al., 1991). Administration of 500 or 1500 ppm 13C or DIM