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Creator:: Nazari, Mohamad
Abstract:: Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
Resource Type:: Dissertation
Full Text:: ....................................................................... 40! Figure S2.11. Cytotoxicity of natural mandelalides B, C and E

Creator:: Abu-Shakra, Salah Suleiman
Abstract:: A biochemical study of aging was conducted on mitochondria from the embryo axes of germinating new and old soybean seeds. Differential phosphorylative efficiency, an average P/O ratio of 3.03 of the new material compared to 1.44 of the old, was obtained when all the co-factors and substrate were provided. No...
Resource Type:: Dissertation
Full Text:: induce aging phe- nomenon. (c) The mutation theory which relates aging to the accumulation of

Creator:: Sun, Albert Yung-Kwang
Resource Type:: Dissertation
Full Text:: . Wilbert F. Steele, Dr, Morris A. Johnson, Chongchit Tengumnuay and Kenneth C. Olson, and also to Weldon

Creator:: Gregg, Charles Thornton
Resource Type:: Dissertation
Full Text:: $*"ffi.{r*S f,}"rtx,nn}"sL s*ppar* Xs ffise&efu:).y **kxe*wle&Ss&. 'l'ABLE C•F CC Nr EN_ilS I

Creator:: Steele, Wilbert Francis
Abstract:: Oxidative phosphorylation and related reactions, particularly as affected by 2, 4-dinitrophenol (DNP), were studied with mitochondria and submitochondrial particles isolated from the flight muscle of the blowfly (Phormia regina) and housefly (Musca domestida). In the presence of a phosphate acceptor, the mitochondria oxidized pyruvate rapidly, and this was tightly coupled...
Resource Type:: Dissertation
Full Text:: Tengumnuay, Morris A. Johnson, Albert Y. Sun, Weldon K. Johnston, Betty M. Christensen, and Jean C

Creator:: Chavez, Juan D.
Abstract:: Oxidative stress is recognized as an important underlying factor in the pathogenesis of many degenerative diseases as well as normal senescence. The free radicals, reactive oxygen species (ROS) and electrophiles produced during oxidative stress are capable of modifying nucleic acids, lipids and proteins. There are a variety of oxidative modifications...
Resource Type:: Dissertation
Full Text:: 4………………… 211 Appendix C Supplemental Material For Chapter 5………………… 289 Appendix D

Creator:: Wu, Jianyong
Abstract:: The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
Resource Type:: Dissertation
Full Text:: such as ubiquinione, ascorbic acid (vitamin C) and the lipid soluble α-tocopherol (vitamin E), serve

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