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Filtering by: Resource Type Dissertation Subject Peptides

The synthesis of β-alanyl peptides

Creator:

Sharkey, Hubert Joseph

Resource Type:

Dissertation
Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

Creator:

Erve, John C. L.

Abstract:

Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...

Resource Type:

Dissertation
Synthesis and opioid activity of conformationally constrained dynorphin A analogues

Creator:

Arttamangkul, Seksiri

Resource Type:

Dissertation
Gas-phase fragmentation chemistry of protonated peptide ions

Creator:

Bythell, Benjamin James

Abstract:

The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...

Resource Type:

Dissertation
Electron molecule interactions of amino acids and peptides

Creator:

Figard, Benjamin J.

Abstract:

Electron-biomolecule interactions are a biologically relevant field of study because there are several ion fragmentation techniques that have come to the forefront in mass spectrometric analysis that involve the interaction of charged peptides and free electrons. By studying the electron energies that cause fragmentation in neutral amino acids, amino acid...

Resource Type:

Dissertation