Index Catalog // ScholarsArchive@OSU

Creator:: Ryu, Byung-Woo
Resource Type:: Dissertation
Full Text:: -p-dioxin Exposure in C57BU6J Male Ahd/A-Mice. Abstract approved: ( H W. Schaup The halogenated

Creator:: Shepherd, David M.
Abstract:: The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Resource Type:: Dissertation
Full Text:: comprised the Kerkvliet laboratory. I would like to thank both Linda Steppan and Julie Oughton for all

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation
Full Text:: Linda B. Steppan Technical support; critical review of experimental design Zhen Yu Technical

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: ; critical review of data and manuscnpt Linda B. Steppan Technical support; critical review of experimental

Creator:: Marshall, Nikki B.
Abstract:: The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
Resource Type:: Dissertation
Full Text:: , critical review of experimental design Linda B. Steppan Technical support and design, critical review

Creator:: Huang, Wentian
Resource Type:: Dissertation
Full Text:: Lawrence, Dr. Jefferson Fowles, Dr. Gregory DeKrey, Linda Steppan, Julie Oughton, Rodney Prell, David

Creator:: Roy, Shukla
Resource Type:: Dissertation
Full Text:: the ARNT antibody and Linda Stephan for her help during animal experiments. I would also like to

ScholarsArchive@OSU