Although the biological occurrence of 5'-methylthioadenosine
(MTA) and 5-methylthioribose (MTR) were recognized more than a half
century ago, very little light has been cast on the physiologic significance
of either substance. My studies were designed to extend
our knowledge of the metabolism of MTA and to determine if this pathway...
In many traditional computer graphics applications, rendered scenes typically utilize 3D meshes to represent objects within an environment. As the demand to further improve the realism of graphics applications increases, such as for movies and games, it is becoming more important to represent the inner volumes of object meshes. In...
3D vector tomography has been explored and results have been achieved in the last few decades. Among these was a reconstruction formula for the solenoidal part of a vector field from its Doppler transform with sources on a curve. The Doppler transform of a vector field is the line integral...
Bacteria are abundant in marine environments. They play important roles in nutrient cycling and form symbiotic interactions with eukaryotes. However, the vast majority of bacterial taxa are difficult to maintain in laboratory cultures, meaning that most microbiological research of the past century has focused on a small subset of bacteria....
This research work focuses on the mechanism of 1/f noise in GaAs
resistors on semi-insulating substrates and 1/f noise due to temperature
fluctuations in heat conduction in resistors, diodes, and bipolar transistors. The
goal of this research is to generate accurate models to explain physical origin of 1/f
noise in...
The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...
Post-secondary education institutions across the United States are increasingly allocating resources to promote international education exchange programs as a pedagogical praxis to develop students into global citizens. Underlying such notions of global citizenship is the assumption that students will also develop a stronger post-national or cosmopolitan identity as a result...
Organic semiconductors are of interest for (opto)electronic applications due to their low cost, solution processability, and tunable properties. Natural product-derived organic pigments have attracted attention due to their extraordinary environmental stability and unexpectedly good optoelectronic performance, in spite of only partially conjugated molecular structures. Fungi-derived pigments are a naturally sourced,...
Assessing the risk from exposure to a chemical mixture in the environment can seem prohibitively challenging. Most components of the mixture are not readily identifiable, chemicals may interact to cause other-than-additive toxicity, and the number of potential combinations of environmental contaminants is enormous. These challenges can make it seem impossible...
About one-quarter of the U.S. adult population lives with a disability, yet ableist presentations of disability as a tragedy in need of a cure (i.e., the medical model) continue to predominate, even in higher education. Previous, qualitative research showed that people with disabilities (PWDs) desire changes in individual and societal...
Adolescence is a developmental stage marked by crystallization in individuals’ sense of identity (Erikson, 1994; Harter, 1999). Research on positive youth development stresses the ways in which thriving trajectories during adolescence contribute to positive lifelong outcomes (Lerner & Overton, 2008; Scales, Benson, & Roehlkepartain, 2011) A symbolic interactionism perspective (Mead,...
This manuscript-style dissertation explores Diné (Navajo) education and teaching in the context of a research project that negotiated the demands of both Navajo Nation IRB and Oregon State University IRB. In the first manuscript, the researcher examines his journey of using cultural resilience strategies to succeed in the education system...
The experiences of Latinx youth are well-studied in U.S. schools, yet, few studies have focused on their experiences in Community Based Educational Spaces (CBES). CBES continue to be on the periphery of Education research despite the potential affordances of youth-led work in such out-of-school spaces (Baldridge, 2020). At the same...
Positive youth development posits that all youth possess the capacity to change and grow as they interact with their contexts. That capacity is activated and nurtured by a beneficial ecological environment often unavailable for homeless youth. Only a limited number of studies focus on the positive development and strengths of...
Different racial/ethnic groups often perceive the realities of the campus environment differently: This difference in perspective and the attendant reactions can be a factor in student satisfaction or dissatisfaction. A quantitative survey administered in 1996 and 1999 revealed that African-American students on the campus of a diverse two-year community college...
The War Production Board issued limitation order 85 in April 1942 in order to conserve fabric and manpower needed for the war effort. The L-85 order froze the silhouette so no major style changes in women's wear would occur during the war. It is clear that on the one hand...
The topic of this study is the cultural impact of the computer in a school. "Impact" is 'defined as the cultural consequences of intended and unintended learning that occur when computers are used in the school. The major theoretical orientations of the work include the concepts of manifest and latent...
The persistent underrepresentation and marginalization of women of color in the disciplines of science, technology, engineering, and mathematics (STEM) are well-documented. However, much of the existing literature takes an “either/or” approach, focusing solely on the experiences of either “women” or “minorities” in STEM, without adequately examining the unique experiences of...
Cancer-related fatigue (CRF) disproportionately effects hematologic cancers when compared to solid tumor malignancies. Self-management of CRF has received increasing attention in solid tumor cancers, however, fatigue self-management in hematologic cancers has received significantly less systematic investigation. The purpose of this research was to determine effective strategies for self-managing fatigue across...
This dissertation draws on ethnographic data and political ecological theory to analyze the experience of residents living in the IBM-Endicott Superfund site in Endicott, New York. Combining in-depth narratives and quantitative measures from a household survey, it highlights residents' perceptions of 1) environmental health risk, 2) risk mitigation, 3) deindustrialization...
Human development researchers consider adolescence a rich time for interest development and identity exploration. A relatively new movement in the Free-Choice Learning (FCL) arena, the Maker movement, offers learners interest-driven, experiential, often collaborative, and process-oriented activities ranging from game design (computer-based and otherwise) and robotics, to sewing LEDs into clothing...
This dissertation aims to provide a comprehensive portrayal of doula care in the lives of pregnant and parenting adolescent mothers. The purpose of this research was to examine the relationships between psychosocial stress, social support, institutionalized constraints, and their impacts on health and well-being among adolescent mothers in the Northwestern...
Community engaged scholarship has gained attention as public universities begin to answer calls to return to their roots of serving the public good. The scholars at the heart of community engagement play an important role in this mission, but their experiences in the academy are not well understood. As institutional...
Critical consciousness (CC) and hopeful future expectations (HFE) are believed to promote positive development in youth who face structural inequalities (Callina et al., 2014; Heberle et al., 2020; Mcwhirter & McWhirter, 2008). Although both CC and HFE hold promise for enhancing the positive development of oppressed youth, gaps in the...
Entrepreneurship is regarded as a viable way for women to enter the economy and improve their quality of life (Morris et al., 2018). However, little attention has been paid to understanding how women, and specifically women of color, utilize their ways of knowing to learn entrepreneurship. Grounded in Chicana/Latina feminism...
Men today are doing more household labor than in previous generations, but research suggests that gender still strongly influences household labor. A great deal of labor goes into creating family rituals, which may be central carriers for gender construction. Weddings, in particular, are rituals based on a gender dichotomy that...
Deaf students in mainstream colleges are withdrawing at an alarming rate. Approximately 70% of the 123,000 deaf students enrolled in 2,300 colleges across the United States will not persist until graduation. This qualitative study examined what factors in the academic and social environment are linked to deaf college students' perceptions...
Behavioral self-regulation has emerged as an important predictor of academic success as early as preschool. Few studies, however, have examined ways to improve children's behavioral self-regulation in preschool, prior to formal school entry. This dissertation includes two studies examining a pilot intervention using classroom games to improve behavioral self-regulation with...