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  • Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

    Creator:
    Woo, Youn-Hi
    Abstract:
    This dissertation details the investigation of an alternate pathway to isoprenoids that occurs in plants and microorganisms, the non-mevalonate pathway. This exploration of the pathway focuses on the second step, the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...
    Resource Type:
    Dissertation
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    , Dr. Phil Proteau for his support, continual inspiration, and endless patience as a mentor, in

  • Studies on isoprenoid biosynthesis in Euglena gracilis

    Creator:
    Kim, Dojung
    Abstract:
    This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
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    Dissertation
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    thank my major Professor, Philip J. Proteau, for his support, guidance, and patience throughout my

  • Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

    Creator:
    Phaosiri, Chanokporn
    Abstract:
    The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
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    Dissertation
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    foremost, II would like to thank my major professor, Dr. Philip Proteau for his advice, guidance, and

  • Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

    Creator:
    Fernandes, Roberta P. M.
    Abstract:
    In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
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    Dissertation
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    Inhibitors. Abstract approved: hilip/(Proteau In recent years, the methyl erythritol phosphate (MEP

  • Studies toward the synthesis of coibamide A and analogues

    Creator:
    Li, Dong
    Abstract:
    Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...
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    Dissertation
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    : Philip J. Proteau Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian

  • Sex role discrimination and preference in preschool aged children

    Creator:
    Sugawara, Alan Iwao, 1939-
    Abstract:
    The two major purposes of this study were: (1) to test the assumption that the IT Scale for Children (standard-ITSC) can be used as a measure of both appropriate sex role discrimination and sex role preference with preschool aged children, and (2) to extend previous studies in these areas by...
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    Dissertation
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    in elude: My committee who guided me through this doctoral program: Dr. J. Philip O'Neill, Head

  • Analysis of dating decisions made by college freshmen women while random and steady dating

    Creator:
    Hartness, Helen Thun
    Abstract:
    The purpose of this study was to seek information regarding issues around which dating decisions were made and some of the steps college freshmen women considered in deciding for or against certain courses of action while random and steady dating. A second more general purpose was to determine if the...
    Resource Type:
    Dissertation
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    . J. Philip O'Neill, Head, Department of Family Life, Dr. Lester A. Kirkendall, Professor Emeritus of

  • Impact of a human sexuality course on university students' knowledge, attitudes, and acceptability of sexual behaviors

    Creator:
    Schmall, Vicki L.
    Resource Type:
    Dissertation
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    me through the doctoral program: Dr. J. Philip O'Neill, Head of the Family Life Department; Dr. Alan

  • Self-consistent relativistic model for pion-nucleon scattering

    Creator:
    Wu, Huachuan
    Abstract:
    We introduce a relativistic model for pion-nucleon scattering which includes an elementary delta dressed by its decay. Crossing-symmetric single-particle exchange is augmented by parametrized multiple-scattering interactions, with covariant sideways form factors in both 3- and 4-field vertices. Causality is enforced by dispersion relations. Unitary fits to observed on-shell amplitudes are...
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    Dissertation
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    Abstract approved: Philip J. Siemens We introduce a relativistic model for pion-nucleon scattering which

  • Pion content in nucleon using finite renormalization scheme with spectral amplitude separation of ghosts

    Creator:
    Symmes, Jonathan P.
    Abstract:
    We develop a technique to express the nucleon pole strength and bare mass in terms of renormalized quantities. Starting from a general unrenormalized self energy we determine the bare mass and the pole strength. For determining the pion content of the nucleon we discuss the leading renormalization loop. We relate...
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    Dissertation
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    approved: Philip J. Siemens We develop a technique to express the nucleon pole strength and bare mass in

  • Spatial evaluation of Lyapunov exponents in Hamiltonian systems

    Creator:
    Stanley, Paul Elliott
    Abstract:
    A new method for evaluating the Lyapunov exponent for a Hamiltonian system involves a spatial evaluation, rather than a numerical time integration. The introduction of a novel vector field to the phase space allows the Lyapunov exponent to be expressed in a form that does not involve time. The Lyapunov...
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    Systems Abstract approved. Philip J. Siemens A new method for evaluating the Lyapunov exponent for a

  • Contribution from two on-shell pion exchange in nucleon-nucleon scattering

    Creator:
    Kheaomaingam, Nupan
    Abstract:
    We used recent phenomenological form factors to calculate the effect of on-shell two-pion exchange in nucleon-nucleon scattering below the two-pion production threshold. As expected, the contributions of partial wave amplitudes are all negligible. We also noticed that the relativistic spin-operator decomposition of the scattering amplitude is not unique at certain...
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    in Nucleon-Nucleon Scattering Abstract approved: Philip J. Siemens We used recent

  • Unusual quantum effects in scattering wave functions of two-dimensional cage potentials

    Creator:
    Rowe, Kirk, 1966-
    Abstract:
    We exhibit long-lived resonances in scattering from two-dimensional soft cage potentials comprised of three and four Gaussian peaks. Specific low-energy resonances with very narrow width are shown to correspond to classical multiple-reflection events. These states have much larger probability densities inside the cage than outside and mimic bound states in...
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    Dissertation
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    Scattering Wave functions of Two-Dimensional Cage Potentials. Abstract approved: Philip J. Siemens We