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  • Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

    Creator:
    Laskar, Paul A.
    Abstract:
    The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was investigated in several buffered aqueous media, in mixed solvent and in nonaqueous solvent systems, and in the presence of several electrolytes and nonelectrolytes. The degradation rate constant of BCNU in these systems was calculated from the parameters of the linear regression of...
    Resource Type:
    Dissertation
    Full Text:
    privacy Dr. James W. All The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was

  • Prolonged duration of action of dyphylline through prodrugs

    Creator:
    Panomvana, Duangchit
    Resource Type:
    Dissertation
    Full Text:
    . Redacted for privacyAbstract approved: ?'Dr. James W. Ayres A series of four diesJrs and four monoesters

  • The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

    Creator:
    Olson, Stephen Carl
    Abstract:
    The relative bioavailability and pharmacodynamics of tolbutamide from two different commercially available tablet products has been evaluated in healthy subjects in a single dose cross over study. Products were aged by exposing tablets to 98% relative humidity for 3 days at ambient temperature which was found to differentially affect both...
    Resource Type:
    Dissertation
    Full Text:
    PRODUCTS Abstract Approved: Redacted for Privacy James W. Ayres, PhiDO The relative bioavailability and

  • Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

    Creator:
    Huang, Hua-pin
    Abstract:
    Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
    Resource Type:
    Dissertation
    Full Text:
    Administration of Prodrugs in Rabbits and Pigs Abstract approved: Redacted for privacy/ mJaes W. Ayres, P1

  • New product formulations, pharmacokinetics and bioavailability of dyphylline

    Creator:
    Chang, Shyi-Feu
    Abstract:
    Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
    Resource Type:
    Dissertation
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    Bioavailability of Dvohvlline Redacted for PrivacyAbstract approved: Product UJames w. Ayres formulation and

  • Bioadhesive polymers in drug product formulations

    Creator:
    Tavipatana, Wattanaporn
    Abstract:
    Gastric retention time of single unit dosage forms in swine was found to be much longer than in humans. It was concluded that swine are not a good animal model to study GI transit time of nonerodable or slowly eroded dosage forms. Noneradable and slowly eroded dosage forms used to...
    Resource Type:
    Dissertation
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    approved: _Redacted for Privacy ((/ James W. Ayres, Ph /. / Gastric retention time of single unit dosage

  • New product formulations and pharmacokinetics of acetaminophen

    Creator:
    Borin, Marie T.
    Resource Type:
    Dissertation
    Full Text:
    solutions: 1) 10% w/w starch in distilled water, 2) 10% w/w gelatin (175 bloom, Dyna Gel, Inc., Calumet

  • New product formulation and multiple dose pharmacokinetics of acetaminophen

    Creator:
    Sahajwalla, Chandrahas G.
    Abstract:
    Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
    Resource Type:
    Dissertation
    Full Text:
    Dr. James W. Ayres for his guidance and support during the course of my study and preparation of

  • Formulation studies of lactic acid-producing bacteria for oral administration

    Creator:
    Liou, Yow-Hwa Grace
    Abstract:
    Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
    Resource Type:
    Dissertation
    Full Text:
    Bacteria for Oral Administration Redacted for Privacy Abstract approved: Dr. Jame$ fq1. Ayres Effects of

  • New acetaminophen products : formulation development and bioavailability

    Creator:
    Mansell, Libbie J.
    Abstract:
    Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
    Resource Type:
    Dissertation