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Filtering by: Creator Barciszewski, Jan Resource Type Dissertation

Deoxyguanosine triphosphate, a possible target for reactive oxygen species-induced mutagenesis

Creator:

Tassotto, Mary Lynn Benka

Abstract:

Intracellular dNTP pool sizes are highly asymmetric, with dGTP usually comprising 5 to 10% of the sum of the dNTP pools. The work presented in this dissertation addresses the question of whether the underrepresentation of dGTP is related to its potential to be oxidized by reactive oxygen species. 8-oxo-guanine is...

Resource Type:

Dissertation