Index Catalog // ScholarsArchive@OSU

Exploring Protein Structure: Seeing the Forest and the Trees

Creator:: Brereton, Andrew E.
Abstract:: Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Andrew E. Brereton

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:: Perkins, Arden
Abstract:: Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
Resource Type:: Dissertation
Full Text:: thank the members of the Karplus lab— Camden Driggers, Kelsey Kean, and Andrew Brereton—for being such

Complexity in host-pathogen dynamics : dispersal uncertainties, metapopulation persistence and the role of a changing climate

Creator:: Xie, Yang
Abstract:: Emerging infectious diseases impact both human and wildlife populations. Infectious agents, in particular the aquatic fungus Batrachochytrium dendrobatidis (chytrid), have an influential role in driving global amphibian population declines. The emergence of the chytrid fungus has aspects of both geographic spread as well as climate shifts altering environmental conditions and...
Resource Type:: Dissertation
Full Text:: Abstract approved: _____________________________________________________________________ Andrew R

Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

Creator:: Kean, Kelsey M.
Abstract:: The function of a protein is defined by its three-dimensional structure, and in understanding the three-dimensional structure of a protein, we gain an understanding of its function and mechanism. Protein structures, especially at high resolution, can provide detailed insights into many elements of enzyme function and catalysis – identifying residues...
Resource Type:: Dissertation
Full Text:: for introducing me to the Tarntip lunch special. Thank you to Arden Perkins and Andrew Brereton for

Structural investigations to understand the mechanisms of two proteins involved in sulfur chemistry : SsuE and cysteine dioxygenase

Creator:: Driggers, Camden McCullough
Abstract:: Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
Resource Type:: Dissertation
Full Text:: Andrew Brereton to the lab. I would like to thank the undergraduates who let me practice my mentoring

Effects of spatial scale and heterogeneity on avian occupancy dynamics and population trends in forested mountain landscapes

Creator:: Frey, Sarah J. K.
Abstract:: Population trends and patterns in species distributions are the major currencies used to examine responses by biodiversity to changing environments. Effective conservation recommendations require that models of both distribution dynamics and population trends accurately reflect reality. However, identification of the appropriate temporal and spatial scales of animal response, and then...
Resource Type:: Dissertation
Full Text:: maximum temperatures. Sites with a higher proportion of the canopy over 10m in height (E) and higher

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Creator:: Miller, Galen W.
Abstract:: Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
Resource Type:: Dissertation
Full Text:: May 4, 2012. Title: Vitamin E and the α-Tocopherol Transfer Protein During Zebrafish Embryogenesis

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Creator:: Kim, GilSoo
Abstract:: The first part of this manuscript is about the total synthesis of the aspidosperma alkaloids leuconoxine, melodinine E and mersicarpine. Our synthetic strategy used a radical translocation-conjugate addition cascade to construct the core of the natural product. Specifically, a vinyl radical was generated from the homolysis of the C–I bond...
Resource Type:: Dissertation
Full Text:: , Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress

Parental attitudes, home environment, and the cognitive ability of Korean kindergarten children

Creator:: Cho, Bokhee
Abstract:: This study examined the relationships among authoritarian parental attitudes, home environments, parental attitudes toward the children's freedom, and the cognitive performances of kindergarten children. Socioeconomic status of the family and sex of child and parent differences were also examined. Subjects consisted of 73 pairs of Korean parents and their children....
Resource Type:: Dissertation
Full Text:: Children --Scale II 109 Appendix E : Summary of ATFC-II Response 113 LIST OF FIGURES Figure Page 1

Signatures in the Subsurface - Big & Small Data Approaches for the Spatio-Temporal Analysis of Geologic Properties & Uncertainty Reduction

Creator:: Rose, Kelly Kathleen
Abstract:: Despite more than two centuries of exploration, including more than six million deep wellbores with depths exceeding 40,000 feet in some parts of the world, our ability to constrain subsurface processes and properties remains limited. Characteristics of the subsurface vary and can be analyzed on a variety of spatial scales....
Resource Type:: Dissertation
Full Text:: Properties & Uncertainty Reduction Abstract approved: Andrew J. Meigs Despite

ScholarsArchive@OSU

Exploring Protein Structure: Seeing the Forest and the Trees

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Complexity in host-pathogen dynamics : dispersal uncertainties, metapopulation persistence and the role of a changing climate

Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

Structural investigations to understand the mechanisms of two proteins involved in sulfur chemistry : SsuE and cysteine dioxygenase

Effects of spatial scale and heterogeneity on avian occupancy dynamics and population trends in forested mountain landscapes

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Parental attitudes, home environment, and the cognitive ability of Korean kindergarten children

Signatures in the Subsurface - Big & Small Data Approaches for the Spatio-Temporal Analysis of Geologic Properties & Uncertainty Reduction

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