The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Cell migration is fundamental for physiological processes such as immune re-sponses, wound healing and development. It is also a critical characteristic of metastatic cancer cells. An extensive amount of studies have focused on 2D sub-strates in order to understand the mechanism of cancer metastasis. However, much less is known about...
Cancer cell migration in three-dimensional extracellular matrix is a major cause of death for cancer patients. Although extensive studies have elucidated detailed mechanism of single cell 3D invasion and cell-ECM interaction, 3D collective cancer invasion is still poorly understood. 3D collective migration models have unveiled unexpected degrees of diversity and...
At the intersection of basic science research and clinical relevance, cancer metastasis and cell invasion is a multifaceted problem that has been investigated for the past several decades. Importantly, cancer cell plasticity, the ability of a single cell to change its phenotype without genetic mutations in response to environmental cues,...
The structure and mechanics of tissues affect many important cellular functions such as migration, differentiation, and growth. Mechanical interactions between cells and the extracellular matrix (ECM), as well as ECM-mediated mechanical communication between cells, plays a part in coordinating collective cellular dy- namics during critical processes such as morphogenesis, tissue...
Cell signaling under external stimulation is a critical mechanism that governs many biological processes such as cell proliferation, cell migration, and cell apoptosis, etc. For multicellular organisms, the ability to synchronize heterogeneous individual cellular responses through intercellular communication is crucial to maintain normal functionality. However, even though the biological pathways...
Machine learning applied to computer architecture has rapidly transitioned from a theoretical novelty to being a driving force behind design, control, and simulation in practically all components. These machine-learning-based methodologies are further notable for their scalability to increasingly complex design challenges, which has allowed these methodologies to surpass the prior...
The Machine Learning (ML) algorithms are increasingly explored in varies of fields including designing and optimizing computer systems. Recent research, such as optimizing memory/cache prefetching by ML training or predicting traffic pattern in throughput processors, also exhibits a promising future of introducing ML into computer system design and optimization. Throughput...
Social scientists have studied people's responses to disasters for many decades, and behavioral commonalities and variations are summarized in different mental schemes/models in disaster studies. Integrating those findings from social science into evacuation simulation can improve simulation accuracy and eventually better support decision-making and disaster preparedness. However, this kind of...
Solanum species differ in their degree of frost tolerance and cold acclimation capacity. Cultivated potato species of Solanum tuberosum L. are frost-sensitive, incapable of cold acclimation, and have a maximum freezing tolerance of –3°C. Solanum commersonii Dun is frost-tolerant and can survive to –5ºC pre-acclimation and –10ºC post-acclimation. Breeding attempts...