Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
A programming paradigm can be defined as a model or an approach employed in solving a problem. The results of the research described in this document demonstrate that it is possible to unite several different programming paradigms into a single linguistic framework. The imperative, procedural, applicative, lambda-free, relational, logic and...
Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
The N=88 isotones lie on the onset of nuclear deformation and have a complicated nuclear structure. To better understand this region, the nuclear levels of ¹⁵⁰Sm were studied in three different β decay experiments. De-populating γ-rays were measured using the 8π spectrometer, an array of 20 Compton suppressed Ge detectors....
The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
The major phenolics of 'd' Anjou' pear (Pyrus communis L.)
tissues were chlorogenic acid and arbutin. Chlorogenic acid
inhibited mycelial growth and spore germination of Penicillium
expansum and mycelial growth of Mucor piriformis. Slight increases
in radial growth and spore germination of Botrytis cinerea occurred
on chlorogenic acid media. Chlorogenic...