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  • Kinesin-14 Motors with Novel Motility Behaviors and Functions

    Creator:
    Feng, Guangxi
    Abstract:
    Cell division, arguably the most important event during the life cycle of the eukaryotic cell, is achieved through a complicated yet beautiful machinery. The mitotic spindle — a microtubule-based bipolar structure—is the cellular machinery responsible for the correct segregation of the genetic material, chromosomes. The protein-based nanomachines termed molecular motors...
    Resource Type:
    Dissertation
    Full Text:
    like to thank my committee members – Dr. Bo Sun, Dr. Ethan Minot, Dr. Andy Karplus and Dr. Victor Hsu

  • In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

    Creator:
    Blizzard, Robert J.
    Abstract:
    The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
    Resource Type:
    Dissertation
    Full Text:
    experiments. I want to thank the Johnson Lab for use of their fluorimeter as well as the Barbar, Karplus

  • Tracking Excited State Proton Transfer and Inhibition with Ultrafast Raman and Transient Absorption Spectroscopy

    Creator:
    Oscar, Breland G.
    Abstract:
    In this dissertation, excited state proton transfer (ESPT) and its inhibition in solution and protein environments are revealed using both femtosecond transient absorption (fs-TA) spectroscopy and femtosecond stimulated Raman spectroscopy (FSRS). Using a tunable Raman pump to enhance transient vibrational features of the photoacidic chromophore HPTS in methanol and methanol...
    Resource Type:
    Dissertation

  • Fecal Bacteroidetes host distributions and environmental source tracking

    Creator:
    Dick, Linda K.
    Abstract:
    Contamination of recreational and shellfish waters with fecal pollution is a major water quality issue with associated economic impacts and human health risks. Reliable fecal source identification and rapid, quantitative analyses are essential components of risk assessment. Enteric bacteria that are endemic to specific hosts have a potential role as...
    Resource Type:
    Dissertation
    Full Text:
    advice: Drs. Stephen Giovannoni, Dan Rockey, Andy Karplus, and Alex Stone. I thank T.J. Brodeur, Mike

  • Dietary organosulfur and organoselenium compounds as HDAC inhibitors

    Creator:
    Nian, Hui
    Abstract:
    Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
    Resource Type:
    Dissertation

  • Molecular investigation of the cnidarian-dinoflagellate symbiosis and the identification of genes differentially expressed during bleaching in the coral Montipora capitata

    Creator:
    Hauck, Laura L.
    Abstract:
    Cnidarians, such as anemones and corals, engage in an intracellular symbiosis with photosynthetic dinoflagellates. Corals form both the trophic and structural foundation of reef ecosystems. Despite their environmental importance, little is known about the molecular basis of this symbiosis. In this dissertation we explored the cnidariandinoflagellate symbiosis from two perspectives:...
    Resource Type:
    Dissertation
    Full Text:
    along the way; my thanks to Kevin Ahern, Andy Karplus, Dahong Zhang, and Larry Curtis. I must also