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  • The Role of Cellular Senescence in the Development of Alzheimer's Disease

    Creator:
    Riordan, Ruben
    Abstract:
    Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
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    Dissertation
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    committee members Dr. Maria Clara Franco, Dr. Kathy Magnusson, Dr. Colin Johnson, and Dr. Kevin Gable

  • An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

    Creator:
    Manchanda, Aayushi
    Abstract:
    Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
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    also like to thank my committee members- Dr Michael Freitag, Dr Kathy Magnusson, Dr Jeff Anderson

  • Identification of Cervical Cancer Key Regulators using Network Biology Approach

    Creator:
    Vyshenska, Dariia
    Abstract:
    Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
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    Dissertation
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    grateful to my committee members, Stephen Ramsey, Jane Ishmael, and Kathy Magnusson for their vital

  • Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

    Creator:
    Wan, Xuemei
    Abstract:
    Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...
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    Dissertation
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    for drug screening. I owe a special thanks to my committee members Dr. Conroy Sun, Dr. Kathy

  • Assessment of the neuropathological consequences of vitamin E deficiency

    Creator:
    McDougall, Melissa Quin
    Abstract:
    Cognitive impairment, or cognitive decline, a noticeable and measurable decline in cognitive abilities (e.g. memory and learning) that exceeds those attributed to normal aging, represents an early symptom of neurodegeneration and increased risk for progression to more severe dementias, such as Alzheimer's disease (AD). While the complex etiology of these...
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    Dissertation
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    of my doctoral committee, Drs. Donald Jump, Kathy Magnusson, Robert Tanguay, and Theresa Filtz

  • Pheromone Variation in Plethodontid Salamanders

    Creator:
    Chouinard, Adam J.
    Abstract:
    Plethodontid salamanders have served as an informative vertebrate system for studying the role of chemical signals in facilitating social and reproductive behaviors. Individuals produce complex mixtures of chemicals from multiple glandular regions. In total, these secretions convey a wide variety of information, and are important for numerous inter- and intraspecific...
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    thank Dr. Magnusson for her support and assistance as my Graduate Council Representative. Each of

  • Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

    Creator:
    Beilby, Pamela R.
    Abstract:
    Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
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    Dissertation
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    , Kathy Magnusson, Barb Taylor, and Tory Hagen, who have provided guidance and encouragement

  • The role of innate immunity in cnidarian-dinoflagellate symbiosis

    Creator:
    Poole, Angela Z.
    Abstract:
    Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
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    Dissertation
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    and teaching endeavors. I would also like to thank Eli Meyer, Michael Freitag, Mike Blouin, Kathy

  • Temperature stress, gene expression, and innate immunity at the onset of cnidarian-dinoflagellate symbiosis

    Creator:
    Schnitzler, Christine E.
    Abstract:
    The intracellular mutualism between cnidarians and photosynthetic dinoflagellates (genus Symbiodinium) is responsible for the physical and trophic structure of diverse coral reef ecosystems. This relationship, based on nutrient exchange, allows for high productivity in tropical waters, which are generally nutrient-poor environments. Numerous environmental stressors currently threaten the health of corals,...
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    for Joey at my proposal meeting while Joey was away in Thailand on sabbatical. I thank Kathy

  • Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

    Creator:
    Bajaj, Gaurav
    Abstract:
    EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
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    Dissertation
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    , Dr. Kathy Magnusson, and Dr. David Williams for their guidance and encouragement. I would also