Index Catalog // ScholarsArchive@OSU

Host-Induced Gene Silencing in Black Cottonwood for Control of Septoria Canker: Efficacy and Non-Target Impacts

Creator:: Gordon, Michael I.
Abstract:: Septoria canker remains the most important disease of poplars in intensively managed forest plantations. Genetic resistance has long been considered the best way to manage for this disease. Transgenic resistance mediated by RNA silencing against pathogens and pests (HIGS: host-induced gene silencing) has shown promise in other pathosystems but has...
Resource Type:: Dissertation
Full Text:: Gordon for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on December

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

Creator:: Alto, Sarah I.
Abstract:: Skeletal muscles provide several functions, including, yet not limited to, voluntary body movement and locomotion, posture and body position, and soft tissue support. Skeletal muscles also play a role in metabolism, requiring energy to facilitate contraction. Each skeletal muscle serves a different purpose despite seeming to perform the same task....
Resource Type:: Dissertation
Full Text:: . Alto for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on June 8

An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

Creator:: Manchanda, Aayushi
Abstract:: Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
Resource Type:: Dissertation
Full Text:: for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on October 22

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Creator:: Fraser, Valerie N.
Abstract:: Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
Resource Type:: Dissertation
Full Text:: . Fraser for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on August 2

Exploring the Limits of Ligation Rate and Specificity in Protein Immobilization Using the Genetically Encoded Tetrazine Ligation

Creator:: Bednar, Riley M.
Abstract:: Immobilized proteins are integral components of a number of important technologies, including the principal component of many biosensors, as functional coatings in various implants, as catalysts is industrial biosynthesis, and as the building blocks of next-generation nanotechnologies. Despite their ubiquity, relatively little is known about the processes that shape immobilized...
Resource Type:: Dissertation
Full Text:: friends who I’ve made out here in Corvallis, as well as throughout the Molecular and Cellular Biology

Non-Canonical Nedd8 Conjugation Mediated Targeted Protein Degradation and Direct Antigen Presentation

Creator:: Vijayasimha, Kartikeya
Abstract:: While the role of ubiquitin in protein degradation is well established, the role of other ubiquitin-like proteins (UBLs) in protein degradation is less clear. Neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) is the UBL with the highest level of amino acid identity when compared to ubiquitin. Here we...
Resource Type:: Dissertation
Full Text:: for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on April 21, 2021

Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

Creator:: Head, Brian A.
Abstract:: Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________________________ Major Professor, representing Molecular and Cellular Biology

Outliers: The Unusual Characteristics of Marine Carbon-Oxidizing Bacterial Cells Adapted to Oligotrophic Conditions

Creator:: Noell, Stephen E.
Abstract:: Oligotrophic bacteria are adapted to low nutrient concentrations. As most of the ocean is oligotrophic (low in nutrients), oligotrophic bacteria thrive in the ocean and make up the majority of planktonic cells. Because of this, oligotrophs are crucial to oceanic nutrient cycles. However, marine oligotrophic bacteria are dwarfed by their...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Stephen E. Noell for the degree of Doctor of Philosophy in Molecular and Cellular Biology

From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Creator:: Meeuwsen, Joseph C.
Abstract:: Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
Resource Type:: Dissertation
Full Text:: Joseph C. Meeuwsen for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented

Development of Computational, Visualization, and Molecular Tools for Fungal and Oomycete Community Ecology

Creator:: Foster, Zachary Stephen Longiaru
Abstract:: Oomycetes are an important group of organisms with a variety of ecological roles similar to fungi. Although many are well-studied plant pathogens known for their devastating effects on agricultural systems, most are little-studied saprobes and parasites of plants and animals in nearly every ecosystem on earth. The advent of affordable...
Resource Type:: Dissertation
Full Text:: Longiaru Foster for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on June

ScholarsArchive@OSU

Host-Induced Gene Silencing in Black Cottonwood for Control of Septoria Canker: Efficacy and Non-Target Impacts

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Exploring the Limits of Ligation Rate and Specificity in Protein Immobilization Using the Genetically Encoded Tetrazine Ligation

Non-Canonical Nedd8 Conjugation Mediated Targeted Protein Degradation and Direct Antigen Presentation

Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

Outliers: The Unusual Characteristics of Marine Carbon-Oxidizing Bacterial Cells Adapted to Oligotrophic Conditions

From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Development of Computational, Visualization, and Molecular Tools for Fungal and Oomycete Community Ecology

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