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  • Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

    Creator:
    Wang, Jing
    Abstract:
    Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
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    Dissertation
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    mitochondrial thiol proteome is a subset of proteins inside mitochondria particularly vulnerable to oxidative

  • Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

    Creator:
    Song, Zifeng
    Abstract:
    Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
    Resource Type:
    Dissertation
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    Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

  • Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

    Creator:
    Tzeng, Shin-Cheng
    Abstract:
    Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
    Resource Type:
    Dissertation
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    Elucidating Adaptive Responses of the Hepatic Mitochondrial Proteome in an Alcoholic Fatty Liver Disease Model

  • The Genetics of Larval Fitness in the Pacific Oyster: Responses to Acidified Seawater and Temporally Dynamic Selection Processes

    Creator:
    Durland, Evan R.
    Abstract:
    The Pacific Oyster (Crassostrea gigas) is one of the most economically and ecologically significant shellfish species worldwide. In the Pacific Northwest United States (PNW), the sustainability oyster stocks is increasingly threatened by ocean acidification (OA), which has had significant negative effects on the aquaculture industry in this region over the...
    Resource Type:
    Dissertation
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    for the degree of Doctor of Philosophy in Fisheries Science presented on May 14, 2019. Title

  • Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

    Creator:
    Baarda, Benjamin I.
    Abstract:
    Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
    Resource Type:
    Dissertation
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    challenged by the gonococcus’s tremendous modulation of its surface proteome, evasion of immune responses

  • Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

    Creator:
    McNamara, Michael J.
    Abstract:
    Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
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    Dissertation
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    to more thoroughly characterize the surface-exposed proteome of M. avium, particularly in the

  • Proteomic analyses of marine bacteria

    Creator:
    Sowell, Sarah M.
    Abstract:
    Proteins are the metabolic machines of the cell and as such, the study of proteins could illuminate the dominant biological activities that are occurring within cells and reveal how an organism interacts with its environment. Here, we used proteomic techniques to study the abundant marine bacterium SAR11 both as an...
    Resource Type:
    Dissertation
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    devoting significant resources to proteome remodeling. A mechanism for a global stationary-phase response

  • Characterization of the transition to the progamic phase in Zea mays pollen

    Creator:
    Smyth, Johanna C.
    Abstract:
    The transition of mature pollen to the progamic phase represents an important step in the regulation of plant sexual reproduction. The progamic phase encompasses the initiation of pollen tube germination, growth of the pollen tube through the stigma (the silk in maize) and concludes with fertilization of the female gametophyte....
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    Dissertation
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    decreasing in abundance at 30 minutes post-germination. Quantitative profiling of the proteome and

  • Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

    Creator:
    Huang, Lin
    Abstract:
    Oxidative stress is defined as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
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    Dissertation
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    oxidative stress and for profiling responses of the proteome to oxidative stress in the context of

  • Alternative splicing in the obligate biotrophic oomycete pathogen, Pseudoperonospora cubensis

    Creator:
    Cumbie, Jason S.
    Abstract:
    Oomycetes are some of the most devastating pathogens, causing upwards of billions of dollars of damage each year to plants. They also diminish ecological diversity and health through the destruction of trees and shrubs. The genome sequence of Pseudoperonospora cubensis, an obligate plant pathogen and causative agent of downy mildew...
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    Dissertation
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    transcriptome and proteome complexity to influence gene regulation and phenotypic plasticity. Because of the