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  • Three Sites are Better than One : Exploring Multivalency in LC8 Binding Partners

    Creator:
    Clark, Sarah A.
    Abstract:
    Hub proteins bind a large number of partners to facilitate structural changes and downstream protein interactions. LC8, a highly conserved protein homodimer, is a unique hub that regulates the activity of proteins in a wide range of cellular processes by binding to intrinsically disordered regions. With many of these systems,...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Sarah A. Clark for the degree of Doctor of Philosophy in Molecular and

  • Fecal Bacteroidetes host distributions and environmental source tracking

    Creator:
    Dick, Linda K.
    Abstract:
    Contamination of recreational and shellfish waters with fecal pollution is a major water quality issue with associated economic impacts and human health risks. Reliable fecal source identification and rapid, quantitative analyses are essential components of risk assessment. Enteric bacteria that are endemic to specific hosts have a potential role as...
    Resource Type:
    Dissertation
    Full Text:
    . My lab mates, Sarah Walters, Tom Jones, and Melissa Younger provided friendship, humor, and patience

  • Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

    Creator:
    Baker, Kasie J.
    Abstract:
    The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
    Resource Type:
    Dissertation
    Full Text:
    Sav. Rather the formation of the Hpo-Sav complex is mediated by the SARAH domains present in both

  • Who Benefits from Development Aid? Exploring Agroforestry Technology Adoption, Food Security, and Path Dependence in Rural Tanzania

    Creator:
    Bruck, Sonia R.
    Abstract:
    Rural farmers in Tanzania depend on subsistence agriculture for their livelihood. Poor soil conditions, and the danger of drought, increases the risk of cyclical poverty conditions. Aid organizations, including the World Agroforestry Centre (ICRAF) and the Millennium Development Projects (MDP), as well as industrial tobacco industry, have provided development programs...
    Resource Type:
    Dissertation
    Full Text:
    , Dr. Robert Bruck, Dr. Isaac Bruck, Sarah Rosner, Dr. Wendy Harpham, Naomi Schlessel, my nephews and