Index Catalog // ScholarsArchive@OSU

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Creator:: Zhang, Yong
Abstract:: Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...
Resource Type:: Dissertation
Full Text:: activity but completely abrogated Gαq-stimulated activity in vitro, indicating the C-tail is important

Expression and G protein coupling of the M2 muscarinic acetylcholine receptor in Sf9 insect cells

Creator:: Mosser, Valerie A.
Resource Type:: Dissertation
Full Text:: independent pathways requires protein kinase C and involves the smaH G protein raf in the activation of ERK

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation
Full Text:: Nicholas G. Kesinger for the degree of Doctor of Philosophy in Pharmacy presented on September 8th, 2009

G, a language based on demand-driven stream evaluations

Creator:: Placer, John R.
Abstract:: A programming paradigm can be defined as a model or an approach employed in solving a problem. The results of the research described in this document demonstrate that it is possible to unite several different programming paradigms into a single linguistic framework. The imperative, procedural, applicative, lambda-free, relational, logic and...
Resource Type:: Dissertation
Full Text:: for G. This goal was also realized. The G interpreter consists of approximately 5000 lines of C code

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Creator:: Li, Xin
Abstract:: This dissertation is separated into two parts according to the two major distinct research projects. In Part I, the full account of synthetic studies toward C10-functionalized lycopodium alkaloids is described. In Part II, the detailed discussion on the exploration of the Pummerer cyclization methodology and its application to the total...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Rich G. Carter This dissertation is separated into two parts according to the two major

The ascorbic acid requirements of older adolescents

Creator:: Davey, Bessie Louise
Abstract:: The concentration of ascorbic acid in the plasma was determined on four levels of ascorbic acid intake for seven day periods in 1946-47 and on three levels of ascorbic acid intake for ten day periods in 1947-48. The subjects, eight girls and eight boys, were 16 to 19 year old...
Resource Type:: Dissertation
Full Text:: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60 C. Total Daily Intake of Ascorbic Acid and Daily Plasma Ascorbic Acid Values for Adolescent Boys

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation
Full Text:: Amphidinolide C; Part II: Computational Study on Proline Sulfonamide- catalyzed Aldol Reaction

Chiral synthesis of monic acid C

Creator:: Theramongkol, Parinya
Abstract:: Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...
Resource Type:: Dissertation
Full Text:: d,e,f,g Se Ph Bn0 0 --OBn 18 b,c i,j,k 21 ( R = SiPh2t-Bu ) 19 15 10 Reagents: a) PhSeCl

C-SHIFT, Quantile Theory, and Assessing Monotonicity

Creator:: Logan, Paul R.
Abstract:: DNA microarray technology is a powerful tool for analyzing patterns in gene expression data for thousands of genes. Due to a number of systematic variations in microarray experiments, the raw gene expression data is often obfuscated by undesirable technical noises. Various normalization techniques were designed in an attempt to remove...
Resource Type:: Dissertation
Full Text:: (2.9), we have ‖Cα‖2F =‖C̃‖2F + 2M M∑ i=1 α2i +M 2 v2(α) + 4 ( 1TC̃α ) + 2a2 − 2c v(α)− 4Mav(α

Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: .; Gunnarsson, I.; Bishop, W. R.; Kreutner, W.; Horan, A. C.; Patel, M. G.; Gullo, V. P.; Puar, M. S. J

ScholarsArchive@OSU

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Expression and G protein coupling of the M2 muscarinic acetylcholine receptor in Sf9 insect cells

Ascorbylation- the biological relevance of covalently bound ascorbic acid

G, a language based on demand-driven stream evaluations

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

The ascorbic acid requirements of older adolescents

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Chiral synthesis of monic acid C

C-SHIFT, Quantile Theory, and Assessing Monotonicity

Studies towards the total syntheses of (+)-phomactins A, D and G

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