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  • Exploring Asian and Asian American Specific Body Mass Index Cut-Points

    Creator:
    Lee, Lauren J.
    Abstract:
    Background: Body Mass Index (BMI) is used as a quick and inexpensive tool to measure populations at risk for a number of metabolic and chronic conditions. In part due to its simplicity, BMI has been criticized for its inaccurate prediction concerning health outcomes. Due to the diversity in the United...
    Resource Type:
    Honors College Thesis
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    measure populations at risk for a number of metabolic and chronic conditions. In part due to its

  • Measuring Past Networks of Cultural Transmission: The Haskett Projectile Point

    Creator:
    Stone, Samantha R.
    Abstract:
    Advances in technology such as 3D digital scanning and spatial analysis software have provided archaeologists with novel data. Specifically, these methods increase the researcher's ability to measure artifact morphology and past networks of cultural transmission, to potentially track the movement of past peoples and ideas through space and time. This...
    Resource Type:
    Honors College Thesis
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    variability between two samples of Haskett projectile points, one from the Haskett Locality in Idaho and one

  • Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

    Creator:
    O'Donnell, Edmond Francis
    Abstract:
    DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
    Resource Type:
    Honors College Thesis
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    spontaneous and DNA damage-induced mutation rates, reduced apoptotic responses, and is associated with

  • Mutations of CenH3 Domains and their Effect on Chromocenter Localization and Meiosis in Neurospora crassa

    Creator:
    Ferrer, Sarah Theresa
    Abstract:
    In recent years, non-coding DNA has received much attention within the scientific community. This attention has not only illuminated the mystery behind functionally important regions like the centromere, but has also brought to light additional important questions regarding centromere mechanisms, inheritance, and cellular recognition by the kinetochore, a protein complex...
    Resource Type:
    Honors College Thesis
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    in Biochemistry and Biophysics presented on May 31st, 2013. Title: Mutations of CenH3 Domains and

  • A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

    Creator:
    Geisler, Mark S.
    Abstract:
    Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
    Resource Type:
    Honors College Thesis
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    silencing and H3K4me in promoting euchromatin. Mutations to histones, particularly H3K27M, H3K36M, and

  • Empathy-Induced Distress: A Psychophysiological Approach

    Creator:
    Karabinas, Isabella M.
    Abstract:
    Empathy is considered a significant motivator of prosocial behavior. Increasing evidence suggests that feelings of personal distress associated with empathy may be stronger or weaker according to the form of perspective taking that an empathizer utilizes. The aim of the present study was to further quantify the stress consequences and...
    Resource Type:
    Honors College Thesis
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    ) examined the differences in physiological and psychological arousal induced by affective and cognitive

  • The Effects of Vitamin E on the Lifespan of Caenorhabditis elegans Strains with Mitochondrial Mutations

    Creator:
    Kusuma, Danika N.
    Abstract:
    Although assays have been done on the effects of vitamin E alpha-tocopherol (ɑ-tocopherol) on the lifespan of wildtype C. elegans, none have been done on the effects of the vitamin on mutant strains with mitochondrial mutations. By using a mev-1 genetic mutant strain of C. elegans with higher levels of...
    Resource Type:
    Honors College Thesis
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    including reperfusion-induced cardiac stunning and reperfusion-induced arrhythmia in rat models (9

  • Exploring the functional effects of Leukemia-promoting natural mutations in the tumor suppressor protein, BCL11B

    Creator:
    Wisner, Heather
    Abstract:
    Thymocytes, cells of the thymus gland, undergo developmental steps that enable them to properly mature into T-cells. Errors in gene expression may lead to improper maturation and potentially mass proliferation of dysfunctional thymocytes, a hallmark of leukemia or lymphoma. BCL11B is a tumor suppressor and transcriptional regulatory protein that is...
    Resource Type:
    Honors College Thesis
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    mutations that mimic BCL11B point mutations found in leukemia patients both within and outside zinc finger

  • Arsenic and Zinc Deficiency Induced Changes in Pancreatic Beta Cells

    Creator:
    Cao, Annie L.
    Abstract:
    Pancreatic beta cells produce and release insulin, a vital hormone that regulates blood glucose levels, and their dysfunction contributes to the development of diabetes mellitus. Dietary zinc deficiency and exposure to the toxicant inorganic arsenic have both independently been associated with diabetes, although the effects of their combination on pancreatic...
    Resource Type:
    Honors College Thesis
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    Arsenic and Zinc Deficiency Induced Changes in

  • Understanding Drivers of Glacier Length Variability Over the Last Millennium

    Creator:
    Huston, Alan C.
    Abstract:
    Changes in glacier length reflect the integrated response to local fluctuations in temperature and precipitation, but when do such changes indicate forced climate change, and when do they indicate natural variability? In this study, we simulate the past ~1000 years of glacier length variability across the globe using the 3-stage...
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    Honors College Thesis
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    for which the inter-annual variability in summer and winter mass-balance is known (e.g., Medwedeff