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Filtering by: Resource Type Masters Thesis Subject Heparin

Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

Creator:

Fry, Allyson Kaye

Abstract:

Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...

Resource Type:

Masters Thesis
Determining cytokine induced vascular maturity throughimmunohistochemical double-staining

Creator:

Hosack, Luke William

Abstract:

As a major natural component of the extracellular matrix (ECM), hyaluronic acid (HA) is an excellent choice for biomimetic, biocompatible therapeutic materials. Furthermore, thiol-modified forms of HA are capable of forming macroporous hydrogels that allow for both controlled cytokine release and extensive vessel in-growth. It has previously been shown that...

Resource Type:

Masters Thesis
Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF

Creator:

Pike, Daniel B.

Abstract:

Biocompatible hydrogels composed of covalently crosslinked, chemically modified hyaluronan (HA), gelatin (Gtn), and heparin (Hp) were synthesized for controlled release of human vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF). We hypothesized that inclusion of small quantities of heparin in these gels would result in regulated growth...

Resource Type:

Masters Thesis