In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health.
The first case study investigated...
Members of the deltocephaline leafhopper genus Giprus Oman
live on grasses, primarily in the desert-scrub, chaparral, and
marine sand dune communities of western North America. Of 16
known species, 10 are undescribed. Recharacterization of the genus
results in exclusion of Laevicephalus incongruus Oman. Differentiation
of species is primarily dependent on...
Why are the fast Fourier transform and the fast
Hadamard transform fast? A transform can be computed by
multiplying a matrix times a vector, which normally requires 0(n²) operations. The matrices corresponding to
these transforms can be rearranged to eliminate redundant
computations resulting in O(nlogn) operations.
We investigate algebraic reasons...
The FLEX/REFLEX paradigm is applied to the description of a computer program system. The paradigm is shown to be relevant and appropriate to computer program systems and to advantageously display and structure the general hierarchical characteristics of computer program systems. Program systems characterized in the paradigm are described both holistically...
The behavior of a metal vapor plasma arc in a vacuum arc remelting (VAR) furnace is believed to contribute to the formation of defects in reactive metal and super-alloy ingots. Industry standard instrumentation, which includes electric current and voltage measurements, can asses the stability of an arc but cannot predict...
Biologists need tools to see the structural relationships encoded in biological sequences (strings). The Walking Tree heuristics calculate some of these relationships. I have designed and implemented graphic presentations which allow the biologist (user) to see these relations. This thesis contains background information on the biological sequences and some background...
The genus Coenonycha contains 30 described species of small to
medium sized scarabs. They are found in the arid and semi-arid
regions of western United States and northern Baja California. The
adults feed at night on several genera of xerophylous plants.
An examination of the male genitalia of the 19...
The stereospecific reagent-controlled homologation (StReCH) of boronic esters with enantioenriched carbenoid species generated in situ by the addition of organolithium initiators to stereodefined α-chloroalkyl aryl sulfoxides was previously reported. The reaction of an organolithium with an α-chloroalkyl aryl sulfoxide ostensibly generates an α-chloroalkyllithium via sulfoxide-lithium exchange; however, the true nature...
Xanthohumol [XN, (E)-6´-methoxy-3´-(3-methylbuten-2-yl)-2´,4´,4´´-trihydroxychalcone], the principal prenylated chalcone from hops, and its 2,3-dihydro- (DXN) and O6-desmethyl-2,3-dihydro- (DDXN) congeners, are of potential utility for the amelioration of metabolic syndrome; however, their complex bioactivity profiles cannot be properly studied and understood without access to appropriately produced synthetic materials.
In the first part of...