Phospholipase C enzymes hydrolyze the rare membrane lipids phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2) PIP into inositol triphosphate (IP3) and diacylglycerol (DAG). Phospholipase C enzymes of the β subtype (PLC-β) function specifically in the signal transduction pathways regulated by Gαq-coupled seven transmembrane receptors. These signaling pathways link plasma membrane receptor activation...
The discovery of novel compounds with antibacterial properties continues to be critically important.3 One potential source of such compounds is the cryptic genome of fungi known to produce biologically active molecules. A kmt6 mutant of the cereal pathogen Fusarium graminearum was previously developed through a histone H3 lysine 27 methyltransferase...
Seasonal Affective Disorder (SAD) is a mood disorder that is characterized by depressive symptoms that onset and remit at the same times each year. Whereas few people (about 1%) experience problems severe enough to be labeled SAD, many people (estimates range from 30%-90%) may experience mild to moderate changes in...
The smartphone is changing the way individuals interact with one another in society. Given the instant accessibility and multitude of socially iconic features, the contemporary handheld device grants users an unprecedented level of connectedness. However, despite the new breadth of access, perhaps the depth of the resulting social networks is...
Objective: In 2018, suicide was the leading cause of death for individuals between the ages of 10-24 in Oregon (OHA, 2019) and was the second leading cause of death for this age range in 2020 (OHA, 2021). In 2019, 12% of Black high school students reported a suicide attempt in...
We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....
The purpose of this project is to study which methyl-accepting chemotaxis proteins (MCPs) are related to chemotaxis of Vibrio cholerae. 44 MCP mutant strains were tested in seven different chemoattractants and the resulting swarm circle size was compared to that of C6706 lac-Z wildtype. Several genes were identified that resulted...
Seasonality is defined as a change in mood and behavior with the seasons. Research shows there is a possible connection between vitamin D levels and mood (Murphy & Wagner, 2008; Lansdowne & Provost, 1998). Given that vitamin D is produced when skin is exposed to sunlight and varies with sun...
The goal of this research was to analyze what different types of perceived barriers affect student veterans' access to mental healthcare services. Previous research has shown that veterans who return from combat and later attend universities are not receiving adequate mental healthcare for mental health problems, including Post-Traumatic Stress Disorder...