Index Catalog // ScholarsArchive@OSU

Creator:: Kyme, Pierre, Thoennissen, Nils H., Tseng, Ching Wen, Thoennissen, Gabriela B., Wolf, Andrea J., Shimada, Kenichi, Krug, Utz O., Lee, Kunik, Muller-Tidow, Carsten, Berdel, Wolfgang E., Hardy, W. David, Gombart, Adrian F., Koeffler, H. Phillip, and Liu, George Y.
Abstract:: The myeloid-specific transcription factor, CCAAT/enhancer-binding protein epsilon (C/EBPε) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans, a condition that confers susceptibility to Staphylococcus aureus infection. We found that C/EBPε-deficient mice are severely affected by infection with S. aureus, and C/EBPε...
Resource Type:: Article
Full Text:: . doi:10.1172/JCI62070. research article The Journal of Clinical Investigation http://www.jci.org

Creator:: Campbell, Yan, Fantacone, Mary L., and Gombart, Adrian F.
Abstract:: Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs...
Full Text:: :803-811. doi 10.1172/JCI30142. 37. Yuk JM, Shin DM, Lee HM, Yang CS, Jin HS, Kim KK, Lee ZW, Lee SH

Creator:: Ito, Matthew K. and Watts, Gerald F.
Abstract:: Homozygous familial hypercholesterolemia (HoFH) is a rare, genetic disorder characterized by an absence or impairment of low-density lipoprotein receptor (LDLR) function resulting in significantly elevated low-density lipoprotein cholesterol (LDL-C) levels. The cholesterol exposure burden beginning in utero greatly increases the risk for atherosclerotic cardiovascular disease (ASCVD) and premature death. The...
Resource Type:: Article
Full Text:: :10.1172/JCI107332. 11. Soutar AK, Naoumova RP. Mechanisms of disease: genetic causes of familial

Creator:: Yu, Zhen, Wang, Rong, Fok, Wilson C., Coles, Alexander, Salmon, Adam B., and Pérez, Viviana I.
Abstract:: Dietary restriction (DR) is the gold standard intervention used to delay aging, and much recent research has focused on the identification of possible DR mimetics. Energy sensing pathways, including insulin/IGF1 signaling, sirtuins, and mammalian Target of Rapamycin (mTOR), have been proposed as pathways involved in the antiaging actions of DR,...
Full Text:: . 2013;123:3272–3291. doi:10.1172/JCI67674 7. Fok WC, Zhang Y, Salmon AB, et al. Short-term treatment with

Creator:: Greenberg, David E., Sturdevant, Daniel E., Marshall-Batty, Kimberly R., Chu, Jessica, Pettinato, Anthony M., Virtaneva, Kimmo, Lane, John, Geller, Bruce L., Porcella, Stephen F., Gallin, John I., Holland, Steven M., and Zarember, Kol A.
Abstract:: Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species (ROS) due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granulibacter bethesdensis is an emerging Gram-negative pathogen in CGD that resists killing by PMN...
Resource Type:: Article

ScholarsArchive@OSU