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Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:

Ruby, Carl E.

Abstract:

In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...

Resource Type:

Dissertation

Full Text:

2,3,7,8 Tetrachlorodibenzo-p-Dioxin on Antigen-Presenting Cells and Molecular Signaling Pathways in
Mechanisms of accessory cell function in rainbow trout (Oncorhynchus mykiss)

Creator:

Ortega, Henry William

Resource Type:

Masters Thesis

Full Text:

+, sensitive to antigen and mitogen activation, and are found in the adult spleen as the primary resting B-cell