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Filtering by: Creator Bernhardt, Joanna R. Rights Statement Copyright Not Evaluated

Manipulations of Amyloid Precursor Protein Cleavage Disrupt the Circadian Clock in Aging Drosophila

Creator:

Blake, Matthew R., Holbrook, Scott D., Kotwica-Rolinska, Joanna, Chow, Eileen S., Kretzschmar, Doris, and Giebultowicz, Jadwiga M.

Abstract:

Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing the neurotoxic Amyloid-β (Aβ) peptide plays a fundamental role in AD pathogenesis. One of the detrimental...

Resource Type:

Article

Full Text:

Cleavage Disrupt the Circadian Clock in Aging Drosophila Blake, M. R., Holbrook, S. D., Kotwica-Rolinska