Index Catalog // ScholarsArchive@OSU

HarperStaceyEnivronMoleToxComparativeHazardAnalysis.pdf

Creator:: Harper, Bryan, Thomas, Dennis, Chikkagoudar, Satish, Harper, Stacey, and et al.
Abstract:: The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure–toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated...
Full Text:: (EZ) metric of toxicity Harper, B., Thomas, D., Chikkagoudar, S., Baker, N., Tang, K., Heredia

HarperStaceyEnivronMoleToxComparativeHazardAnalysisSupplementaryInformation.pdf

Creator:: Harper, Bryan, Thomas, Dennis, Chikkagoudar, Satish, Harper, Stacey, and et al.
Abstract:: The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure–toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated...
Full Text:: Tang, Alejandro Heredia- Langner, Roberto Lins and Stacey Harper. Online Resource 1: Detailed

BonventreJosephineEMTImpactAminatedSurface.pdf

Creator:: Bonventre, Josephine A., Pryor, Joseph B., Harper, Bryan J., and Harper, Stacey L.
Abstract:: Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...
Full Text:: • Stacey L. Harper Received: 7 August 2014 / Accepted: 14 November 2014 / Published online: 4 December

BonventreJosephineEMTImpactAminatedSurface_SupportingInformation.zip

Creator:: Bonventre, Josephine A., Pryor, Joseph B., Harper, Bryan J., and Harper, Stacey L.
Abstract:: Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...

The impact of aminated surface ligands and silica shells on the stability, uptake, and toxicity of engineered silver nanoparticles

Creator:: Bonventre, Josephine A., Pryor, Joseph B., Harper, Bryan J., and Harper, Stacey L.
Abstract:: Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...
Resource Type:: Article

Evaluating the use of zinc oxide and titanium dioxide nanoparticles in a metalworking fluid from a toxicological perspective

Creator:: Seyedmahmoudi, S. H., Harper, Stacey L., Weismiller, Michael C., and Haapala, Karl R.
Abstract:: Adding nanoparticles (NPs) to metalworking fluids (MWFs) has been shown to improve performance in metal cutting. Zinc oxide nanoparticles (ZnO NPs) and titanium dioxide nanoparticles (TiO₂ NPs), for example, have exhibited the ability to improve lubricant performance, decrease the heat created by machining operations, reduce friction and wear, and enhance...
Resource Type:: Article
Full Text:: perspective S.H. Seyedmahmoudi1, Stacey L. Harper2, Michael C. Weismiller3, and Karl R. Haapala1 1

Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

Creator:: Harper, Bryan, Thomas, Dennis, Chikkagoudar, Satish, Baker, Nathan, Tang, Kaizhi, Heredia-Langner, Alejandro, Lins, Roberto, and Harper, Stacey
Abstract:: The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure–toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated...
Resource Type:: Article

Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish

Creator:: Harper, Bryan J., Clendaniel, Alicea, Sinche, Federico, Way, Daniel, Hughes, Michael, Schardt, Jenna, Simonsen, John, Stefaniak, Aleksandr B., and Harper, Stacey L.
Abstract:: Cellulose is an abundant and renewable resource currently being investigated for utility in nanomaterial form for various promising applications ranging from medical and pharmaceutical uses to mechanical reinforcement and biofuels. The utility of nanocellulose and wide implementation ensures increasing exposure to humans and the environment as nanocellulose-based technologies advance. Here,...
Resource Type:: Article
Full Text:: . Jenna Schardt . John Simonsen . Aleksandr B. Stefaniak . Stacey L. Harper Received: 22 May 2015

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

Creator:: Teeguarden, Justin G., Tan, Yu-Mei, Edwards, Stephen W., Leonard, Jeremy A., Anderson, Kim A., Corley, Richard A., Kile, Molly L., Simonich, Staci M., Stone, David, Tanguay, Robert L., Waters, Katrina M., Harper, Stacey L., and Williams, David E.
Abstract:: Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for...
Resource Type:: Article
Full Text:: . Waters,‡,† Stacey L. Harper,‡,∇ and David E. Williams‡ †Health Effects and Exposure Science, Pacific

S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology

Creator:: Mordorski, Breanne, Pelgrift, Robert, Adler, Brandon, Krausz, Aimee, da Costa Neto, Alexandre Batista, Liang, Hongying, Gunther, Leslie, Clendaniel, Alicea, Harper, Stacey, Friedman, Joel M., Nosanchuk, Joshua D., Nacharaju, Parimala, and Friedman, Adam J.
Abstract:: Nitric oxide (NO) is an essential agent of the innate immune system which exhibits multi-mechanistic antimicrobial activity. Previously, increased antimicrobial activity against E. coli with nitric oxide releasing nanoparticles (NO-np) was demonstrated when combined with glutathione, versus NO-np alone, due to formation of S-nitrosoglutathione (GSNO), a potent transnitrosylating agent. To...
Resource Type:: Article
Full Text:: Leslie Gunther, MSc4 Alicea Clendaniel, BS6 Stacey Harper, PhD6,7 Joel M. Friedman, MD PhD3 Joshua

ScholarsArchive@OSU

HarperStaceyEnivronMoleToxComparativeHazardAnalysis.pdf

HarperStaceyEnivronMoleToxComparativeHazardAnalysisSupplementaryInformation.pdf

BonventreJosephineEMTImpactAminatedSurface.pdf

BonventreJosephineEMTImpactAminatedSurface_SupportingInformation.zip

The impact of aminated surface ligands and silica shells on the stability, uptake, and toxicity of engineered silver nanoparticles

Evaluating the use of zinc oxide and titanium dioxide nanoparticles in a metalworking fluid from a toxicological perspective

Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology

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