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S-adenosylmethionine : [triangle]²⁴-sterol methyltransferase and the regulation of ergosterol biosynthesis in Saccharomyces cerevisiae

Creator:

Bailey, Richard B.

Abstract:

The inhibition of S-aden.osylmethionine: Δ²⁴-sterol methyltransferase (EC 2.1.1.41) activity by endogenous cellular components has been studied in vitro. The principal inhibitors were Na⁺ and K⁺; Cs⁺, NH₄⁺ and Li⁺ were also shown to inhibit the reaction. The inhibition by potassium cation has been studied, and we have found that energy...

Resource Type:

Dissertation
Methionine biosynthesis in Saccharomyces cerevisiae : the one-carbon transfer portion of the pathway

Creator:

Trewyn, Ronny William

Abstract:

The generation of the methyl group of methionine, and is also involved in thymidylic acid and purine biosynthesis. The understanding of the mechanisms and controls involved in one-carbon metabolism is incomplete, and is complicated by the existence of conjugated folate cofactors containing up to seven glutamic acid residues. The information...

Resource Type:

Dissertation