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Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Creator:

Purohit, Sarla

Abstract:

The dihydrofolate reductase gene of bacteriophate T4 has been investigated at the structural level to elucide the unusual regulation of expression of this gene and possible evolutionary relationships between the ohage and drug resistance factors-encoded dihydrofolate reductases (DHFR). A 1.1-kilobase-pair restriction fragment of the T4 multiple mutant dec8 containing frd,...

Resource Type:

Dissertation

Full Text:

OF Sarla Purohit for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on