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Creator:: Tang, Longteng, Liu, Weimin, Wang, Yanli, Zhao, Yongxin, Oscar, Breland G., Campbell, Robert E., and Fang, Chong
Abstract:: Imaging Ca²⁺ dynamics in living systems holds great potential to advance neuroscience and cellular biology. G-GECO1.1 is an intensiometric fluorescent protein Ca²⁺-biosensor with a Thr-Tyr-Gly chromophore. The protonated chromophore emits green upon photoexcitation via excited-state proton transfer (ESPT). Upon Ca²⁺ binding, a significant population of the chromophores becomes deprotonated. It...
Resource Type:: Article
Full Text:: ] Weimin Liu,[a] Yanli Wang,[a] Yongxin Zhao,[b] Breland G. Oscar, [a] Robert E. Campbell,[b] and Chong

Creator:: Wang, Yanli, Tang, Longteng, Liu, Weimin, Zhao, Yongxin, Oscar, Breland G., Campbell, Robert E., and Fang, Chong
Abstract:: Fluorescent proteins (FPs) are luminescent biomolecules that emit characteristic hues upon irradiation. A group of calmodulin (CaM)-green FP (GFP) chimeras have been previously engineered to enable the optical detection of calcium ions (Ca²⁺). We investigate one of these genetically encoded Ca²⁺ biosensors for optical imaging (GECOs), GEM-GECO1, which fluoresces green...
Resource Type:: Article
Full Text:: Studied by Femtosecond Stimulated Raman Spectroscopy Yanli Wang,a Longteng Tang,a Weimin Liu,a

Creator:: Oscar, Breland G., Liu, Weimin, Zhao, Yongxin, Tang, Longteng, Wang, Yanli, Campbell, Robert E., and Fang, Chong
Abstract:: Fluorescent proteins (FPs) have played a pivotal role in bioimaging and advancing biomedicine. The versatile fluorescence from engineered, genetically encodable FP variants greatly enhances cellular imaging capabilities, which are dictated by excited state structural dynamics of the embedded chromophore inside the protein pocket. Visualization of the molecular choreography of the...
Resource Type:: Article
Full Text:: Tanga, Yanli Wanga, Robert E. Campbellb, and Chong Fanga,2 aDepartment of Chemistry, Oregon State

ScholarsArchive@OSU