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The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse

Creator:

Grote, Phillip, Wittler, Lars, Währisch, Sandra, Hendrix, David, Beisaw, Arica, Macura, Karol, Bläss, Gaby, Kellis, Manolis, Werber, Martin, and Herrmann, Bernhard G.

Abstract:

The histone modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the activation state of genes controlling pluripotency, lineage commitment, and cell differentiation. Long non-coding RNAs (lncRNAs) can bind to either complex, and some have been shown to act as modulators of PRC2 or TrxG/MLL activity. Here we show...

Resource Type:

Article

Full Text:

Development despite Rapid Sequence Evolution. Cell 147, 1537–1550. Vidigal, J. a., Morkel, M., Wittler, L