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Filtering by: Committee Member O'Neill, J. Philip Remove constraint Committee Member: O'Neill, J. Philip Rights Statement In Copyright Remove constraint Rights Statement: In Copyright Subject Antibiotics -- Synthesis Remove constraint Subject: Antibiotics -- Synthesis

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  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    N S H N H O OH O O N N NH2 NH2 S H2N O O NH2 S H2N O O Figure 1.1 A) Structure of