Index Catalog // ScholarsArchive@OSU

Creator:: Fry, Allyson Kaye
Abstract:: Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...
Resource Type:: Masters Thesis

Creator:: Hosack, Luke William
Abstract:: As a major natural component of the extracellular matrix (ECM), hyaluronic acid (HA) is an excellent choice for biomimetic, biocompatible therapeutic materials. Furthermore, thiol-modified forms of HA are capable of forming macroporous hydrogels that allow for both controlled cytokine release and extensive vessel in-growth. It has previously been shown that...
Resource Type:: Masters Thesis

Creator:: Pike, Daniel B.
Abstract:: Biocompatible hydrogels composed of covalently crosslinked, chemically modified hyaluronan (HA), gelatin (Gtn), and heparin (Hp) were synthesized for controlled release of human vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF). We hypothesized that inclusion of small quantities of heparin in these gels would result in regulated growth...
Resource Type:: Masters Thesis

Creator:: Joshi, Pranav R.
Abstract:: Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram-positive bacteria, was incorporated into novel block copolymer constructs and tested for retained antibacterial activity. Covalent coupling was achieved by chemical modification of the N-terminal isoleucine to introduce a thiol group. Thiolated nisin derivatives were then linked to poly[ethylene...
Resource Type:: Dissertation

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