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  • Kinetic analysis of avian sarcoma virus integrase in the presteady-state

    Creator:
    Bao, Kogan K.
    Abstract:
    Integrase catalyzes insertion of a retroviral genome into the host chromosome. Following reverse transcription, integrase binds specifically to the ends of the duplex retroviral DNA, endonucleolytically cleaves two nucleotides from each 3'-end (the processing activity), and inserts these ends into the host DNA (the joining activity) in a concerted manner....
    Resource Type:
    Dissertation