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Selfish Little Circles: Transmission Bias and Evolution of Large Deletion-Bearing Mitochondrial DNA in Caenorhabditis briggsae Nematodes

Creator:

Clark, Katie A., Howe, Dana K., Gafner, Kristin, Kusuma, Danika, Ping, Sita, Estes, Suzanne, and Denver, Dee R.

Abstract:

Selfish DNA poses a significant challenge to genome stability and organismal fitness in diverse eukaryotic lineages. Although selfish mitochondrial DNA (mtDNA) has known associations with cytoplasmic male sterility in numerous gynodioecious plant species and is manifested as petite mutants in experimental yeast lab populations, examples of selfish mtDNA in animals...

Resource Type:

Article

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, Dana K. Howe1, Kristin Gafner1, Danika Kusuma1, Sita Ping1, Suzanne Estes2, Dee R. Denver1* 1
The Effects of Vitamin E on the Lifespan of Caenorhabditis elegans Strains with Mitochondrial Mutations

Creator:

Kusuma, Danika N.

Abstract:

Although assays have been done on the effects of vitamin E alpha-tocopherol (ɑ-tocopherol) on the lifespan of wildtype C. elegans, none have been done on the effects of the vitamin on mutant strains with mitochondrial mutations. By using a mev-1 genetic mutant strain of C. elegans with higher levels of...

Resource Type:

Honors College Thesis

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, Kristin Gafner, and Katie Clark, who were all cheerful company during the course of my project during