Index Catalog // ScholarsArchive@OSU

KolluriSivaEnvMolecularToxArylHydrocarbonReceptor_SupplementaryFigures.pdf

Creator:: E. F. O'Donnell, Koch, D. C., Bisson, W. H., Jang, H. S., and Kolluri, S. K.
Abstract:: Identification of new molecular targets for the treatment of breast cancer is an important clinical goal, especially for triple-negative breast cancer, which is refractory to existing targeted treatments. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity. However, the AhR can...
Full Text:: transcribed/translated mouse AhR protein was incubated with RLX or DMSO for 1 h at RT and proteolyzed by

KolluriSivaEnvMolecularToxArylHydrocarbonReceptor.pdf

Creator:: E. F. O'Donnell, Koch, D. C., Bisson, W. H., Jang, H. S., and Kolluri, S. K.
Abstract:: Identification of new molecular targets for the treatment of breast cancer is an important clinical goal, especially for triple-negative breast cancer, which is refractory to existing targeted treatments. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity. However, the AhR can...
Full Text:: , HepG2, and MDA-MB-231 cells. Specifically, treatment with raloxifene for 48 h induced dramatic cell

The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells

Creator:: E. F. O'Donnell, Koch, D. C., Bisson, W. H., Jang, H. S., and Kolluri, S. K.
Abstract:: Identification of new molecular targets for the treatment of breast cancer is an important clinical goal, especially for triple-negative breast cancer, which is refractory to existing targeted treatments. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity. However, the AhR can...
Resource Type:: Article

KangYukiLPIHDAC8STAT3Repress_SupplementaryMaterials.zip

Creator:: Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.
Abstract:: Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...

KangYukiLPIHDAC8STAT3Repress.pdf

Creator:: Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.
Abstract:: Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Full Text:: ., Rajendran, P., Kim, E., Dashwood, W. M., Pinto, J. T., ... & Dashwood, R. H. (2014). HDAC8 and STAT3

HDAC8 and STAT3 repress BMF gene activity in colon cancer cells

Creator:: Kang, Y., Nian, H., Rajendran, P., Kim, E., Dashwood, W. M., Pinto, J. T., Boardman, L. A., Thibodeau, S. N., Limburg, P. J., Löhr, C. V., Bisson, W. H., Williams, D. E., Ho, E., and Dashwood, R. H.
Abstract:: Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Resource Type:: Article

Inhibiting the Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2) enzymewith small molecules for the treatment of cancer

Creator:: Rodgers, Brett, Nishita, Michiru, and Bisson, William H.
Abstract:: Based on recent findings, our hypothesis is that the inhibition of the Receptor tyrosine kinase-like orphan receptor 2 (ROR2) enzyme can lead to tumor suppression. ROR2 are trans-membrane proteins that are part of the receptor tyrosine kinase (RTK) family. ROR2 is generally not expressed in most normal adult tissues and...
Resource Type:: Poster
Full Text:: novel lead compounds for multiple tumor types. Brett Rodgers1 , Michiru Nishita2, William H. Bisson1

BissonWilliamEnvironMoleToxIntestineSelectiveFarnesoid(Supplementary Figures 1-17, Supplementary Tables 1-3 and Supplementary Reference).pdf

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shik Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:: Student’s t-test. *P < 0.05 compared to vehicle-treated mice. (h) Insulin tolerance test (ITT) in vehicle

BissonWilliamEnvironMoleToxIntestineSelectiveFarnesoid.pdf

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shik Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:: , Kristopher W. Krausz1, Jingmin Shi1, Chad N. Brocker1, Dhimant Desai4, Shantu G. Amin4, William H. Bisson5

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Krausz, Kristopher W., Shi, Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Resource Type:: Article

ScholarsArchive@OSU

KolluriSivaEnvMolecularToxArylHydrocarbonReceptor_SupplementaryFigures.pdf

KolluriSivaEnvMolecularToxArylHydrocarbonReceptor.pdf

The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells

KangYukiLPIHDAC8STAT3Repress_SupplementaryMaterials.zip

KangYukiLPIHDAC8STAT3Repress.pdf

HDAC8 and STAT3 repress BMF gene activity in colon cancer cells

Inhibiting the Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2) enzymewith small molecules for the treatment of cancer

BissonWilliamEnvironMoleToxIntestineSelectiveFarnesoid(Supplementary Figures 1-17, Supplementary Tables 1-3 and Supplementary Reference).pdf

BissonWilliamEnvironMoleToxIntestineSelectiveFarnesoid.pdf

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

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