Index Catalog // ScholarsArchive@OSU

Application of Bootstrap Methods in Bioequivalence Studies for Oral Generic Prodrug Products

Creator:: Li, Wenjing
Abstract:: The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ John Mark Christensen The methodology to perform bioequivalence studies for prodrug

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation
Full Text:: : John Mark Christensen The first part of the dissertation is to evaluate the use of proposed and

1) Preparation of Acetaminophen Capsules Containing Beads Prepared by Hot-melt Direct Blend Coating Method 2) Pharmacokinetic Modeling and Monte Carlo Simulations in The Context of Additional Criteria for Bioequivalence Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to Tendinopathy

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation
Full Text:: Tendinopathy. Abstract approved: John M. Christensen The thrust of

Pharmacokinetics of Flunixin in Elephants, Cefovecin in African Lions, and Gamithromycin in Alpacas

Creator:: Alshahrani, Sultan M.
Abstract:: Foot pathology is a real problem in captive elephants. Osteoarthritis is the major concern among musculoskeletal disorders and foot health problems for elephants in North America zoos with one-‐half of Elephants in captivity showing foot health care problems in zoos. A higher ratio of captive Asian elephants (Elephas maximus) is...
Resource Type:: Dissertation
Full Text:: OF THE DISSERTATION OF Sultan M. Alshahrani for the degree of Doctor

Associations Between the PlayerLoad™ Metric and Common IMU-based Physical Activity-Related Measures of Human Movement

Creator:: Dailey, Dakota B.
Abstract:: Over the last 60 years, supplemental strength and conditioning for improving sport performance has gone from being nearly non-existent to a cornerstone feature of elite collegiate, amateur, and professional athletics. Concurrent with this profession-related evolution, technologies for monitoring and tracking physical performance have become more prevalent and useful. As an...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: ______________________________________________________ John M Schuna Jr. Over

Price-Endogenous Farm Technology Adoption and Ex-Ante Economic Impact Assessment

Creator:: Cho, Seojin
Abstract:: Technological growth in agriculture increases crop output but it could lower output price in the market. Economic impact assessment in ex-ante analysis usually does not include these indirect supply responses, which can overestimate the economic potential of new technology. This dissertation provides an integrated farm-level ex-ante impact assessment model to...
Resource Type:: Dissertation
Full Text:: Assessment. Abstract approved: _______________________________________________ John M. Antle

Examining Agricultural Household Welfare through Output Marketing Choices and Land Market Efficiency : Evidence from Rural India

Creator:: Dickson, Caleb
Abstract:: Development research and policy aim to improve household welfare by improving access to assets and economic opportunities (Besley & Burgess 2000; Deininger et al. 2003). In rural and agrarian contexts, these goals may be achieved by well-functioning markets for outputs, inputs, off-farm work, and credit. The status of these markets...
Resource Type:: Dissertation
Full Text:: : ___________________________________________________ John M. Antle Development research and policy aim to improve household welfare by

Identifying Threshold Values of Accelerometer-Determined Moderate-to-Vigorous Physical Activity that Correspond to Self-Reported Compliance to the 2008 Physical Activity Guidelines for Americans : National Health and Nutrition Examination Survey 2003-2006

Creator:: Brier, Julie A.
Abstract:: Current public health guidelines for physical activity (PA) were primarily formulated using evidence collected from a series of prospective cohort epidemiological investigations that measured self-reported PA. In light of this observation, and the known discordance between self-reported and objectively-monitored PA, it remains common for researchers to assess compliance to current...
Resource Type:: Masters Thesis
Full Text:: . Abstract approved: _______________________________________________________ John M. Schuna Jr

Short-term Changes in Objectively Assessed Step-defined Physical Activity in The Wave~Ripples for Change: Obesity Prevention in Active Youth Study

Creator:: Le, Kevin and Schuna, John M., Jr.
Abstract:: The WAVE study is an on-going multicomponent comparative-effectiveness trial aimed at improving nutritional habits, increasing habitual physical activity, and preventing unhealthy changes in body composition among active 14-19 year-old adolescents. Participants were recruited through soccer teams from 13 schools and enrolled in one of two conditions: 1) a novel and...
Resource Type:: Poster
Full Text:: Active Youth Study Kevin Le; John M. Schuna Jr., Ph.D. College of Public Health and Human Sciences

Outcome Distributions in Impact Assessment : Climate Change and Technology Adoption in Pacific Northwest Agriculture

Creator:: Zhang, Hongliang
Abstract:: Increased temperature and precipitation variability and frequent extreme weather events due to climate change pose a threat to farming operations and agricultural communities. The recent IPCC assessment shows that the projected climate change will, on average, reduce wheat yields by 5% in temperate regions without adaptation and even more if...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________ John M. Antle Increased temperature and precipitation variability and frequent extreme weather

ScholarsArchive@OSU

Application of Bootstrap Methods in Bioequivalence Studies for Oral Generic Prodrug Products

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Pharmacokinetics of Flunixin in Elephants, Cefovecin in African Lions, and Gamithromycin in Alpacas

Associations Between the PlayerLoad™ Metric and Common IMU-based Physical Activity-Related Measures of Human Movement

Price-Endogenous Farm Technology Adoption and Ex-Ante Economic Impact Assessment

Examining Agricultural Household Welfare through Output Marketing Choices and Land Market Efficiency : Evidence from Rural India

Identifying Threshold Values of Accelerometer-Determined Moderate-to-Vigorous Physical Activity that Correspond to Self-Reported Compliance to the 2008 Physical Activity Guidelines for Americans : National Health and Nutrition Examination Survey 2003-2006

Short-term Changes in Objectively Assessed Step-defined Physical Activity in The Wave~Ripples for Change: Obesity Prevention in Active Youth Study

Outcome Distributions in Impact Assessment : Climate Change and Technology Adoption in Pacific Northwest Agriculture

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