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Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

Creator:

Saldivar, Joshua C., Miuma, Satoshi, Bene, Jessica, Hosseini, Seyed Ali, Shibata, Hidetaka, Sun, Jin, Wheeler, Linda J., Mathews, Christopher K., and Huebner, Kay

Abstract:

Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile FRA3B/FHIT locus, leading to loss of Fhit protein expression....

Resource Type:

Article

Full Text:

, Seyed Ali Hosseini2, Hidetaka Shibata2¤, Jin Sun2, Linda J. Wheeler3, Christopher K. Mathews3, Kay