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  • Role of myosin heavy chain polymorphism in differential susceptibility of muscle fibers to eccentric contraction

    Creator:
    Choi, Seung Jun
    Abstract:
    Relationships between myosin heavy chain (MHC) isoform content and eccentric-induced damage were investigated in chemically skinned muscle fiber segments. Fibers were subjected to an eccentric contraction standardized for strain magnitude (0.25 fiber length) and velocity (0.50 maximal shortening velocity). Fiber MHC isoform content was identified by SDS-PAGE. Pre- to post-eccentric...
    Resource Type:
    Dissertation
    Full Text:
    members Drs Neil Forsberg and John Mata for their interest in my research and precious suggestions. I

  • Contractile function and calpain activity in mouse skeletal muscle during hypoxia

    Creator:
    Hu, Hui
    Abstract:
    Calcium activated proteases, or calpains, are activated in cardiac muscles under conditions of ischemia/reperfusion and hypoxia. Their activity in skeletal muscle under similar conditions is poorly understood. We tested the hypothesis that hypoxia elevates calpain-mediated proteolysis in isolated glycolytic (extensor digitorum longus, EDL) and oxidative (soleus, SOL) mouse muscles studied...
    Resource Type:
    Masters Thesis
    Full Text:
    equipment; Dr. Neil Forsberg, for providing knowledge on calpain and calpain analysis; Dr. Beth Valentine