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  • Recombination, resistance, and drug discovery in Chlamydia

    Creator:
    Sandoz, Kelsi
    Abstract:
    The intracellular life cycle of Chlamydia has been difficult to study due to the inability to genetically manipulate the bacteria. As a result, indirect methods have been employed to study the pathogen and the aspects that contribute to its unique intracellular life cycle. A wide variety of laboratory adapted strains,...
    Resource Type:
    Dissertation
    Full Text:
    vitro is demonstrated by contemporary examples of mutagenesis, recombination, and genetic

  • Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

    Creator:
    Wang, Qi
    Abstract:
    Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
    Resource Type:
    Masters Thesis
    Full Text:
    addition to the functions discussed above, MMR is also involved in genetic recombination. MMR may affect