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  • Bioprospecting the Chemical Diversity of Plant-associated Fungi

    Creator:
    González-Montiel, Gisela Abigail
    Abstract:
    Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
    Resource Type:
    Masters Thesis
    Full Text:
    . ©Copyright by Gisela A. González-Montiel July 11, 2019 All Rights Reserved Bioprospecting

  • Machine learning approach to improve drug discovery in natural product extracts

    Creator:
    Heussner, Robert T.
    Abstract:
    Current natural product (NP) research is limited by its reliance on bioassay-guided fractionation to identify bioactive compounds in mixtures. Computational approaches may improve NP research by correlating mass spectra (MS) and nuclear magnetic resonance spectra (NMR) of bioactive mixtures to their bioactivity patterns. In this study, I use artificial neural...
    Resource Type:
    Honors College Thesis
    Full Text:
    and Gisela Gonzalez-Montiel for the annotated MS and NMR data that made this work possible. I would

  • Elucidating the Origins of Trends and Selectivities of Organic Reactions through Computations and Data Analysis Techniques

    Creator:
    Richardson, H. Camille
    Abstract:
    In this dissertation, a novel method for analyzing computed transition states (TS) for organic reactions is disclosed. It introduces the use of localization-delocalization matrices as parameters in a linear free energy relationship to determine the transition state interactions responsible for differences in energy between the major and minor TS in...
    Resource Type:
    Dissertation
    Full Text:
    going through this with me. Thank you to Joe Harper, Gisela Gonzolez-Montiel, Taisiia Feoktistova

  • Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

    Creator:
    Zhu, Chenxi
    Abstract:
    Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
    Resource Type:
    Dissertation
    Full Text:
    . Birte Plitzko, Gisela González- Montiel, Mahsa Khoshbakht, and many undergraduate students. I am

  • Quorum-sensing-controlled public goods in Pseudomonas aeruginosa : regulation and application

    Creator:
    Mellbye, Brett L.
    Abstract:
    Cell-to-cell communication by chemical signals, termed quorum sensing (QS), is a common regulatory scheme in the microbial world. Pseudomonas aeruginosa¸ an opportunistic pathogen of burn wounds and cystic fibrosis lungs, uses QS to control the expression of hundreds of genes, particularly those necessary for population level benefits such as biofilm...
    Resource Type:
    Dissertation
    Full Text:
    Bacterial Stress Reponses Second Edition, Chapter 20, p. 349-363, ASM Press Edited by Gisela Storz and

  • In Vitro Evaluation of Therapeutic Laser Treatment on Equine Tendon Fibroblasts

    Creator:
    Husby, Kirsty A.
    Abstract:
    Previous investigations have failed to show benefits of low level laser therapy (LLLT) for tendon healing in horses, contrary to reports in other species. We hypothesized that delivery of LLLT at manufacturer-recommended energy fluence through equine cadaver skin to equine tendon-derived fibroblasts in vitro would increase cell proliferation, metabolic activity...
    Resource Type:
    Masters Thesis

  • The Yellow House: Stories of Place, Space and Community

    Creator:
    Gann, Tamara S.
    Abstract:
    This thesis is an IRB-exempt oral history focused on the non-profit Corvallis Multicultural Literacy Center (CMLC) in Corvallis, Oregon. The CMLC, formerly on 9th Street, was known to many community members as the Yellow House. The Yellow House was a dedicated community-based space where people of all cultures could come...
    Resource Type:
    Masters Thesis
    Full Text:
    4.20 Save the CMLC/Save the Sunflower House button………….…….…………..60 4.21 Maria González, TAAP

  • Nine Native Mexicans families in the Willamette Valley

    Creator:
    Cervantes, Willan A.
    Abstract:
    The Mixteco primarily reside in the Mexican State of Oaxaca in Southwestern Mexico. They have been arriving in larger numbers then ever before to this part of the North American continent in the last twenty years.Their experience is composed of different dynamics compared to those of their mainstream Mexican counterpart....
    Resource Type:
    Masters Thesis
    Full Text:
    observations in his book By The Lake of Sleeping Children, and Harvest of Empire by Juan Gonzalez. It is

  • Nine native Mexicans families in the Willamette Valley

    Creator:
    Cervantes, Willan A.
    Abstract:
    The Mixteco primarily reside in the Mexican State of Oaxaca in Southwestern Mexico. They have been arriving in larger numbers then ever before to this part of the North American continent in the last twenty years.Their experience is composed of different dynamics compared to those of their mainstream Mexican counterpart....
    Resource Type:
    Masters Thesis
    Full Text:
    observations in his book By The Lake of Sleeping Children, and Harvest of Empire by Juan Gonzalez. It is

  • Plague in London : a case study of the biological and social pressures exerted by 300 years of yersinia pestis

    Creator:
    Hall, Alice
    Abstract:
    The Second Pandemic had a profound impact on the people of Europe. In the few years between 1347 and 1350, a new epidemic disease spread across the entirety of Europe and killed between one third and two thirds of the population. While this initial wave was important, the real significance...
    Resource Type:
    Masters Thesis